Adjuvant Therapies Flashcards
Gabapentinoids
Generic and Brand
Gabapentin (Neurontin)
Pregabalin (Lyrica)
Gabapentinoid Uses
Fibromyalgia
Neuropathies
Post-Op
Gabapentinoid Dose Forms
Tablet
ER Tablet
Liquid Solution
Pregabalin Dosing
Lyrica- 75 mg PO BID (Max 600 mg/day)
Neurontin Dosing
100-300 mg PO TID
(max 3600 mg/day)
Clinical Pearls of Gabapentinoids
Renally
Titrate UP
Use in combo
Pregab schedule 5
SNRIs
Generic and Brand
Venlafaxine (Effexor)
Duloxetine (Cymbalta)
SNRI Uses
Fibromyalgia
Neuropathies
SNRI Dose Forms
Capsule/Tablet
ER as well^
Effexor Dosing
37.5-75 mg PO daily (max 225 mg/day)
Cymbalta Dosing
30 mg PO daily x 1 week- Then increase to 60 mg PO daily
(max 60 mg/day)
SNRI Pearls
titrate up
Venlafaxine renal adjustment
Duloxetine C/I in CrCl <30
TCA’s
Brand And Generic
Amitriptyline
(Elavil)
Nortriptyline (Pamelor)
TCA uses
Fibromyalgia
Neuropathies
Migraine Prophylaxis
TCA’s Dose Form
Tablet, Capsule, Oral Solution
TCA dosing
10 mg PO QHS (max 150 mg/day)
TCA clinical Pearls
Last line in Fibromyalgia, Neuropathies
due to SE
Muscle Relaxants
All 5 Brand Names
Cyclobenzaprine (Amrix, Fexmid)
Baclofen ( Lioresal)
Methocarbamol (Robaxin)
Carisolprodol (soma)
Tizanidine (Zanaflex)
Muscle Relaxant
All 5 generic drugs
Cyclobenzaprine (Amrix, Fexmid)
Baclofen ( Lioresal)
Methocarbamol (Robaxin)
Carisolprodol (soma)
Tizanidine (Zanaflex)
Muscle Relaxant Uses
Musculo-skeletal pain/spasms
Muscle relaxant dose forms
Tablet/capsule (IR and ER)
Oral Solution (Baclofen)
IV ( methocarbamol, baclofen)
Amrix Dosing
Cyclo
5 mg PO TID (max 30 mg/day)
Lioresal Dosing
Baclofen
5 mg PO TID (Max 80 mg/day)
Robaxin Dosing
1.5 g PO 3-4x/day (max 8 grams)
Methocarbamol
Soma Dosing
Carisoprodol
250-350 mg PO TID (max 1050 mg/day)
Zanaflex Dosing
2-4 mg PO q8-12h (max 24 mg/day)
Muscle Relaxant Pearls
Short term (3 weeks)
Antiepileptic Brand and Generic
Carbamazepine
(tegretol)
Carbamazepine Dose Forms
ER Cap/Tab
Chewable
Suspension
Carbamazepine Dosing
200-400 mh PO daily in 2-4 divided doses ( max 1200mg/day)
tegretol Clincal Pearls
HLAB 1502 Hyper-sensetivity
Autoinduction of hepatic enzymes
Lidocaine Dose Forms
Patch
Injection
Topical
Capsacian Uses
Muscle pain/joint pain
Neuropathic pain
8 HOURS