Adjunctive Hemostasis

Question 1

Evicel Fibrin Sealant components and mechanism of action

Answer 1

Thrombin and fibrinogen (BAC2)

Combine two components to form fibrin clot independent of patient coagulation profile

Question 2

Evicel indication

Answer 2

An adjunct to hemostasis for use in patients undergoing surgery, when control of bleeding by standard surgical techniques (such as suture, ligature, or cautery) is ineffective or impractical

Question 3

Evicel contraindications

Answer 3

• Do not inject directly into the circulatory system
• Do not use in individuals known to have anaphylactic or severe systemic
reaction to human blood products
• Do not use for the treatment of severe or brisk arterial bleeding
• Do not use EVICEL for spraying in endoscopic or laparoscopic procedures
in those instances where the minimum recommended distance from the
applicator tip to the target site cannot be ensured

Question 4

Evicel thawing instructions

Answer 4

• 2°C to 8°C (refrigerator): thaws within 1 day
• 20°C to 25°C (room temperature): thaws within 1 hour
• 37°C (warm water bath): thaws within 10 minutes and must not be left
at this temperature for longer than 10 minutes. The temperature must not
exceed 37°C

Question 5

Evarrest components

Answer 5

Oxidized regenerated cellulose (ORC) and PG901 Vicryl fibers needle punched into ORC backing

Question 6

Evarrest fibrin sealant patch

Answer 6

Flexible sealant patch embedded with human biologics to provide a durable mechanical structure for integrated clot formation. No preparation required.

Question 7

Surgicel SNoW

Answer 7

Absorbable, bactericidal hemostat serving as a scaffold for platelet adhesion and aggregation that leads to quick clot formation

Question 8

Surgicel SNow benefits

Answer 8

• One layer is more effective than four layers of Surgicel Original
• Enhanced conformability and superior handling
• Non-woven structure increases surface contact to bleeding site
• Up to 25% less product use for cost savings

Question 9

Surgicel Powder mechanism of action

Answer 9

Blood saturates the material, providing a surface for platelet adhesion and aggregation, and initiating clot formation to control continuous oozing on broad surfaces

Question 10

Surgicel Powder benefits

Answer 10

• Quick solution to broad-surface oozing on friable or raw tissues
• No resurface bleeding even after irrigation
• Bactericidal through localized reduction in blood pH
• Absorbs within 7-14 days

Question 11

Surgiflo machanism of action

Answer 11

Flowable gelatin mixed with thrombin provides a matrix for platelet adherence, accelerating the formation of the platelet plug and aids in clot formation

Question 12

Surgiflo advantages over Floseal

Answer 12

Shorter thrombin reconstituion time, vial adapter to eliminate needle sticks, improved flowability