adhesion of cells to form tissues Flashcards
What are cell-cell junctions and what do they depend on?
Cell-cell junctions link cells in tissues and depend on cell-adhesion molecules (CAMs) found in the membranes of adjacent cells.
What is the structure of cell-adhesion molecules (CAMs)?
CAMs are typically proteins with some domains embedded in the phospholipid bilayer and others protruding outward, allowing them to interact with CAMs on adjacent cells.
How do CAMs in adjacent cells form a junction?
CAMs bind their extracellular domains with those of CAMs on adjacent cells. This forms a junction between the cells, either symmetrical (same CAM type) or asymmetrical (different CAM types).
What is the role of cell adhesion in tissues and organs?
Cell adhesion maintains the architecture of tissues and organs and ensures functional relationships between adjacent cells.
How do different types of cell junctions affect substance movement?
Some junctions prevent extracellular movement of substances, while others facilitate it, depending on the tissue’s function.
What role does cell adhesion play in the immune system?
Cell adhesion is crucial for the immune system, helping to regulate interactions between immune cells.
How does cell adhesion affect cancerous tumor cells?
In tumors, strong cell adhesion prevents cells from separating and migrating, which helps to limit the spread of malignancy and metastasis.
