Adenovirus Flashcards
Classify adenovirus
ds, linear DNA genome
Icosahedral capsid
Non-enveloped
What’s significant about adenovirus being a “naked” virus?
Naked = non-enveloped.
Very stable –> survives detergents, low pH (GI tract), and can live outside the body for a long time.
Which protein gives adenovirus over 100 serotypes?
Its function?
The capsids PENTON protein.
They’re attachment proteins and are toxic to cells.
**antibodies to penton give life-long immunity to that serotype
Which protein is useful in detecting AdV infection, but can’t serologically type it?
Hexon protein, another capsid protein to go with penton protein.
**The body makes complement-fixing antibodies to hexon.
How is AdV transmitted?
Inhalation of water droplets (fecal oral route or directly)
Who is at highest risk of respiratory AdV infection?
Kids under 3yo
Who is most susceptible to acute respiratory distress?
Which serotypes is this?
Military people
Serotypes 4 and 7
How do people get AdV eye infections?
Contaminated swimming pools (conjunctivitis) or opthalmic solutions (epidemic keratoconjunctivitis)
What is pharyngoconjunctival fever?
The classic presentation of AdV infection, causing pharyngitis + ocular infection.
Do GI tract AdV infections cause respiratory or ocular infections?
What serotypes are in the GI?
No.
Serotypes 40 and 41
**mostly in kids, second only to rotavirus to cause GI probs
Which AdV serotypes are linked to obesity?
Serotypes 36 and 37
In what way is AdV limited (clinically) in using it as gene therapy?
It provokes a prominent innate immune response that is very necrotic and inflammatory.
Presentation of AdV infection?
Respiratory: cough, fever, sore throat
Ocular: “sand in the eye”, runny nose
GI: diarrhea, vomiting
What time of year is AdV infection endemic?
Late winter, early spring
Where in the body can AdV become latent?
Tonsils, Adenoids, or Peyer’s patches.
Viral shedding continues for 6-18 months
