Adenosine

Question 1

Adenosine

• Trade name:

Answer 1

Adenosine

• Trade name: Adenocard

Question 2

Adenosine

• Class:

Answer 2

Adenosine

• Class: Endogenous Nucleoside

Question 3

Adenosine

• Mechanism of Action:

Answer 3

Adenosine

• Mechanism of Action: Slows conduction through the AV node

Question 4

Adenosine

• Indications: _____

Answer 4

Adenosine

• Indications: PSVT

Question 5

Adenosine

• Contraindications:

Answer 5

Adenosine

• Contraindications:
  
  • 2nd and 3rd degree AV block
  • sick sinus syndrome
  • known hypersensitivity

Question 6

Adenosine

• Adult Dosage:

Answer 6

Adenosine

• Adult Dosage:
  
  • 6 mg rapid IV push over 1-2 seconds, followed by a 20cc saline flush.
  • If PSVT does not convert, 12 mg rapid IVP over 1-2 seconds, followed by a 20cc saline flush.

Question 7

Adenosine

• Pediatric Doasage:

Answer 7

Adenosine

• Pediatric Doasage:
  
  • 0.05-0.1 mg/kg rapid IV/IO push over 1-2 seconds followed by a 5-10cc saline flush.
  • If PSVT does not convert, 0.2 mg/kg rapid IV/IO push over 1-2 seconds followed by a 5-10cc saline flush.

Question 8

Adenosine:

• How supplied:

Answer 8

Adenosine:

• How supplied: 30 mg/mL

Question 9

Adenosine:

• Side/Adverse Effects:

Answer 9

Adenosine:

• Side/Adverse Effects:
  
  • Transient asystole
  • Hyoptension
  • Dyspnea
  • Bronchospasm
  • Facial flushing
  • Headache
  • Chest pressure
  • Nausea

Question 10

Adenosine:

Onset / Duration / Pharmacokinetics:

Answer 10

Adenosine:

Onset / Duration / Pharmacokinetics:

• Immediate / 30-40 seconds / t 1/2 <10 seconds

Question 11

Adenosine:

Pregnancy safety:

Answer 11

Adenosine:

Pregnancy safety: C. Safety not known for nursing.

Question 12

Adenosine:

• Notes:

Answer 12

Adenosine:

• Notes:
  
  • Antagonized by methylxanthines (theophylline, aminophylline, caffeine); may need larger dose.
  • Potentiated by nucleoside transport inhibitors (dipyridamole/Persantine)