Addison's Flashcards
1
Q
Presentation
A
Widespread pigmentation, calcification of auricular cartilages
Associated autoimmune diseases
Check for postural hypotension and electrolytes
2
Q
Causes of primary adrenal failure
A
Autoimmune
TB
Bilateral adrenalectomy
Amyloidosis
Haemochromatosis
HIV
3
Q
Autoantibodies
A
Anti-21-hydroxylase
Anti 17-hydroxylase
4
Q
Diagnostic test
A
9am cortisol - <500nmol/l
Synacthen test - measure ACTH and cortisol after ACTH administration
5
Q
Treatment of adrenal crisis
A
Rapid steroid and fluid replacement
6
Q
Long term management
A
Glucocorticoid and mineralocorticoid replacement
