Addiction - risk factors Flashcards
Outline genes as a risk factor for addiction
We have a genetic predisposition or vulnerability to addiction. Addiction only develops if a person is exposed to a substance—genes increase risk, but do not guarantee addiction.
Why don’t genes alone determine whether someone becomes addicted?
Genes are not inevitable causes. A person must first be exposed to a drug, and whether this happens depends mainly on psychosocial factors such as peer pressure, stress, or environment.
According to Blum (1991), what role does dopamine play in genetic vulnerability to addiction?According to Blum (1991), what role does dopamine play in genetic vulnerability to addiction?
Blum proposed that people vulnerable to addiction have low dopamine levels and fewer dopamine receptors (especially D2 receptors) in the brain’s reward system, making them more likely to seek out substances that increase dopamine.
What is the D2 receptor and how is it linked to addiction?
The D2 receptor is a type of dopamine receptor. A low number of D2 receptors is linked to increased risk of addiction. The number of these receptors is genetically determined.
What did Pianezza et al. (1998) find about the CYP2A6 enzyme and nicotine addiction?
They found that individuals lacking a fully functioning CYP2A6 enzyme metabolise nicotine more slowly and therefore smoke less. Those with the full version of the enzyme are more at risk of nicotine addiction due to faster metabolism.
What does the CYP2A6 enzyme do and how does it relate to genetic vulnerability?
CYP2A6 is responsible for metabolising nicotine. Its expression is genetically determined, meaning some people are more vulnerable to nicotine addiction based on how efficiently they process the drug.
What does the diathesis-stress model say about addiction and genetic vulnerability?
It suggests that addiction arises from an interaction between genetic vulnerability (diathesis) and environmental stressors. Not everyone exposed to stress becomes addicted—only those with the underlying vulnerability are at higher risk.
How does the dopamine receptor gene variant (A1) relate to addiction risk?
The A1 variant of the dopamine receptor gene is linked to lower dopamine function. People with this gene are more likely to become dependent on substances like nicotine and cocaine that activate the brain’s reward system.
What is a strength of genetic explanations for addiction?
They help explain individual differences in addiction risk, even when people share similar environments. Genetics account for why some develop addictive behaviour while others don’t.
What is a limitation of genetic explanations for addiction?
McGue (1997) found stronger genetic links in male alcoholics, but inconsistent results in females. Only 2 out of 5 twin studies found higher concordance in female MZ than DZ twins, suggesting weaker genetic influence in women. This isn’t explained by the genetic risk factor explanation
Outline Kendler et al’s study supporting evidence for genes as a risk factor. How does it support this factor?
used data from the National Swedish Adoption Study. They looked at adults who had been adopted away as children from biological families in which at least one parent had an addiction. These people had a significantly greater risk of developing an addiction themselves (8.6%) compared with adopted away individuals with no addicted parent in their biological family (4.2%). This suggests that the greater the genetic vulnerability the children had, the higher the likelihood of developing an addiction.
What does the self-medication model propose about addiction (stress)?
The self-medication model suggests that individuals use pathological behaviors (e.g., alcohol, drugs, gambling) to cope with psychological symptoms caused by everyday stressors like relationship problems or work stress. The perception that these behaviors help reduce stress can lead to addiction.
How does stress contribute to the initiation and maintenance of addiction?
Stressful events can lead to addiction initiation and maintenance by encouraging people to engage in self-medication behaviors. Moreover, stress during attempts to quit can contribute to relapse and increased cravings, making it harder to break the cycle of addiction.
What did Piazza et al. (1991) discover about stress and addiction in rats?
Piazza et al. showed that stress (via tail pinching) combined with repeated exposure to amphetamines increased dopamine activity, making rats more likely to self-administer the drug. This suggests that stress can enhance the neurobiological effects of drugs, increasing vulnerability to addiction.
How is post-traumatic stress disorder (PTSD) linked to addiction?
PTSD is a stress disorder that can develop after traumatic events (e.g., combat, abuse). People with PTSD are at higher risk of addiction, especially when combined with early childhood trauma, as both PTSD and chronic stress increase vulnerability to addictive behaviors.
What did Epstein et al. (1998) find in terms of the link between childhood trauma and addiction?
Epstein et al. found a strong correlation between childhood rape and adult alcohol addiction, but only for those women diagnosed with PTSD. This suggests that childhood trauma alone does not guarantee addiction; the presence of PTSD or other stressors is a key factor.
What did Arevalo et al. (2008) find about stress and addiction?
Arevalo et al. found that stress was linked to illicit drug use but not alcohol addiction in a sample of women in substance abuse programs. This shows that stress may affect different types of addiction in varied ways.
What is a limitation of the Arevalo et al. (2008) study?
A limitation is that the study used self-report measures, which can be affected by social desirability bias, leading participants to under-report substance use. This could reduce the validity of the findings.
What is a strength of research into stress as a risk factor for addiction?
A key strength is that it offers practical applications. If addiction is linked to stress, then coping strategies for managing stress could reduce the need for addictive behaviors, leading to better prevention and treatment outcomes.
Outline Cleck and Bendy’s study supporting evidence for stress as a risk factor. How does it support this factor?
Cleck & Bendy found that individuals with stress-related psychiatric disorders (e.g., depression, anxiety) often engage in addictive drug use. Chronic stress and traumatic events, like sexual abuse, are linked to increased use of substances like nicotine, alcohol, and cocaine. This supports the idea that stressful events are more likely to lead people to addictive behaviour as a stress reduction technique, therefore suggesting stress as a risk factor to addiction has a degree of validity.
What is one limitation of stress explanations of addiction?
One limitation is that stress’s impact on addiction may vary based on the type of addiction. For example, stress may be a stronger risk factor for certain behaviors (like drug abuse) than for others (like alcohol use).
How do personality characteristics influence addiction according to Eysenck?
Individuals with neurotic and psychopathic traits are thought to be more vulnerable to addiction. These traits may drive people to use substances to escape negative emotions and stress, which can lead to addiction.
What is neuroticism, and how does it relate to addiction?
Neuroticism involves experiencing negative emotions, such as anxiety, depression, and low moods. People high in neuroticism are more likely to experience negative affect and may turn to substances to cope with these emotions, increasing their vulnerability to addiction.
What is psychoticism, and how does it relate to addiction?
Psychoticism is characterized by emotional coldness, aggression, impulsivity, and aggression. People high in psychoticism are more likely to engage in impulsive behavior, such as substance use, without considering the consequences, which may increase their risk of addiction.