addiction and drugs of abuse modified Flashcards
Question: What is addiction defined as?
Answer: Addiction is continued involvement with a substance or activity despite ongoing negative consequences.
Question: What are the two types of addiction?
Answer: The two types of addiction are physiological addiction and psychological addiction.
Question: What is the difference between habit and addiction?
Answer: Habit is a repeated behavior that may be unconscious, whereas addiction is a repeated behavior that occurs by compulsion and causes considerable discomfort if not performed.
Question: What are process addictions?
Answer: Process addictions are behaviors that are known to be addictive because they are mood altering, such as money addictions, compulsive gambling, and work addiction.
Question: What is a severe substance use disorder?
Answer: A severe substance use disorder is characterized by having four or more severe symptoms, such as tolerance, withdrawal, using more than intended amounts, trying unsuccessfully to stop, having physical or psychological problems made worse by the drug, and experiencing problematic relationships.
Question: What are the DSM-5 substance use disorders categorized by?
Answer: The DSM-5 substance use disorders are categorized by a specific substance, such as alcohol, caffeine, cannabis, hallucinogens, inhalants, opioids, sedatives, hypnotics, or anxiolytics, stimulants, and tobacco.
Question: What is tolerance?
Answer: Tolerance is a decline in the effects of a drug with continued use at the same dose, leading to the need for higher doses over time to elicit the same response.
Question: What is dependence?
Answer: Dependence is the adaptation to chronic regular use of a drug, becoming apparent during withdrawal when drug administration ceases or the dose of drug is reduced.
Question: What is craving?
Answer: Craving is the powerful subjective urge to engage in drug taking behavior, often observed in conditions where there is dependence.
Question: What are habits?
Answer: Habits are conditioned responses to environmental stimuli that have been associated previously with reward or absence of punishment.
Question: What are compulsions?
Answer: Compulsions are repetitive and persistent habitual acts that are inappropriate to a given situation and frequently lead to adverse consequences.
DSM-5 Substance Use Disorders
Categorised by a specific substance:
Alcohol
Caffeine
Cannabis (e.g., marijuana)
Hallucinogens
Inhalants
Opioid (e.g., heroin)
Sedatives, Hypnotics, or Anxiolytics (e.g., diazepam)
Stimulants (cocaine, methamphetamine)
Tobacco
Severe substance use disorder
Having four or more severe symptoms, such as:
Tolerance: Larger doses needed; lower dosage does not produce typical effect
Withdrawal: Negative physical and psychological effects from stopping usage
Using more than intended amounts
Trying unsuccessfully to stop
Having physical or psychological problems made worse by drug
Experience problematic relationships.
What neurotransmitter is involved in the reward pathway in addiction?
Dopamine is the neurotransmitter involved in the reward pathway in addiction.
What region of the brain is involved in reward processing?
The nucleus accumbens is the region of the brain involved in reward processing.
What is the effect of chronic drug use on dopamine levels in the reward pathway?
Chronic drug use can lead to decreased dopamine levels in the reward pathway, leading to a reduced ability to experience pleasure and reward from natural sources.
What are the opioid peptides involved in addiction?
Opioid peptides are involved in addiction and are found in the nucleus accumbens, amygdala, and ventral tegmental area.
What is the role of GABA in addiction?
GABA is a neurotransmitter involved in addiction and is found in the amygdala and bed nucleus of stria terminalis.
What neurotransmitter is involved in the acute reinforcing effects of drugs of abuse?
Glutamate is the neurotransmitter involved in the acute reinforcing effects of drugs of abuse.
What is the prefrontal cortex’s role in serotonin pathways?
The prefrontal cortex is involved in serotonin pathways, particularly in regulating mood, anxiety, and depression.
What is the effect of chronic cocaine use on serotonin levels in the brain?
Chronic cocaine use can lead to reduced serotonin levels in the prefrontal cortex, leading to increased impulsivity and risk-taking behavior.
What is the hippocampus’s role in serotonin pathways?
The hippocampus is involved in serotonin pathways, particularly in regulating memory.
What are the potential consequences of chronic opioid use on serotonin pathways?
Chronic opioid use can lead to changes in the serotonin pathways involved in pain perception, leading to increased pain sensitivity and dependence on opioids.
What neurotransmitter is involved in the reward pathway?
Dopamine is the neurotransmitter involved in the reward pathway.