Adaptive Immune System

Question 1

Understand antigen presentation as one of the main links between the innate and the adaptive immune responses

Answer 1

=> antigen presentation: done most commonly by dendritic cells (DC), breakdown into peptide
- presentation of peptide to CD4+ with MHC (anchor proteins and presentation into TCR binding site) = activation of T-cell

Question 2

Define the characteristics of lymphocytes

Question 3

Understand why we have lymphocyte

Answer 3

• pathogen recognition
• developing adaptive response
• production of antibodies
• coordinating response and maintaining memory
• avoiding destruction of self

Question 4

Describe the features of the T cell receptor and the B cell receptor

Question 5

Understand the concept of lymphocyte repertoire selection

Question 6

Understand how immunological memory is generated and maintained

Answer 6

SECONDARY RESPONSES:
- faster, greater magnitude
- memory cells accumulation > naive t-cells
- memory cells react more vigorously when challenging repeat antigen exposure.

Question 7

Define epitope or determinant

Answer 7

the recognisable parts of complex antigens detected by lymphocytes