Acute promyelocytic leukemia Flashcards
1
Q
acute promyelocytic leukemia APL
A
variant of AML
APL represents a medical emergency with a high rate of early mortality
2
Q
Presentation of APL
A
like AML
signs and symptoms of pancytopenia
Unique to APL is a presentation with bleeding secondary to disseminated intravascular coagulation
3
Q
Diagnosis of APL
A
peripheral blast cells
any signs of coagulapthy
treat as suspected APL while awaiting confirmation
The diagnosis of APL is confirmed by the identification of the PML-RARA fusion gene
4
Q
Treatment of APL
A
Induction therapy
ATRA
idarubicin
Consolidation
Tarsenic trioxide
idarubicin
ATRA
Maintenance
ATRA 4
