Acute Phase Proteins

Question 1

Enumerate the acute phase proteins ?

Answer 1

Mnemonic(3C,2F and Pash):-

1. CRP
2. Ceruloplasmin
3. Complement
4. Ferritin
5. Fibrinogen
6. Proclcitonin
7. Alpha 1 antitrypsin
8. Serum amyloid A
9. Haptoglobin

Question 2

Define the negative acute phase proteins ?

Answer 2

During the acute phase ,the liver decreases the production of other proteins(sometimes referred to as negative acute phase proteins).

Question 3

Enumerate the negative acute phase proteins?

Answer 3

1. Albumin
2. Transthyretin(formerly known as prealbumin)
3. Transferrin
4. Retinol binding protein
5. Cortisol binding protein

Question 4

When are the levels CRP commonly measured ?

Answer 4

Levels of CRP are commonly measured in acutely unwell patients.

Question 5

Where is the CRP synthesised ?

Answer 5

Liver

Question 6

What substance the CRP binds to ?

Answer 6

Phosphocholine

Question 7

Where does the CRP bind to phosphocoline ?

Answer 7

1. In bacterial cell wall

2. On those cells undergoing apoptosis

Question 8

What happens after binding of phosphocholine and CRP ?

Answer 8

Activation of complement system.

Question 9

What is the effect of surgery on CRP secretion ?

Answer 9

The CRP rises after surgery.

Levels CRP greater than 150 at 48 hours post operatively are suggestive of evolving complications.