Acute liver failure

Question 1

what are seven signs of acute liver failure?

Answer 1

• weight change
• jaundice
• bruising
• fatigue
• dark urine
• unexplained fever
• fluid retention

Question 2

liver failure of how long is chronic?

Answer 2

26 weeks

Question 3

what is a definition of acute liver failure?

Answer 3

Development of severe acute liver injury with encephalopathy and impaired synthetic function in a patient without recognised cirrhosis or pre-existing liver disease

Question 4

why do people with acute liver failure get encephalopathy?

Answer 4

Build up of toxic compounds not metabolised by the liver

Question 5

what zone is most likely injured after paracetomal poisoning?

Answer 5

Zone three

Question 6

what is the distribution of necrosis in acute hepatitis?

Answer 6

Spotty or patchy hepatocyte necrosis

Question 7

What is the distribution of necrosis in acute hepatic failure?

Answer 7

fulminant/ confluent necrosis which typically affects acinar zone 3

Question 8

what is the typicaly inflammation in acute hepatitis?

Answer 8

Florid lobular and portal lymphocyte rich inflammation, sometimes with eosinophils and plasma cells