acute leukemias Flashcards
what are the origans of leukemia
1827 alfred armand 1st described, 1856 geraman rudolf virchow named it leukemia
what cells are in the myeloid lines
granulocytes monocytes erythrocytes megakaryocytes,
what is the most common genetic syndrome to produce a leukemia in children
downs syndrome
what is more common AML or ALL
AML more common and found mostly in adults
what exposures will increase the risk of leukemia
benzene radiation tobacco and chemotherapies
what more common CML or CLL
CLL underdiagnosed most common in adults under reported 78% 5 year survival rate
what is the presentation of acute leukemia’s
general fatigue, pallor, weakness, bone pain infrequent sternal or long bone, fever and infection with neutropenia, petechiae red mucosa in the buccal of the mouth, retinal hemmorrhage or white plaques in eye, organomegaly.
what should you know about the FB classification
M6 RBC line, M3 APL treated differently
what are auer rods
long crystal on netruphils gives diagnosis of AML
what is leukemia cutis
AML in the skin
how do you make a final diagnosis of most leukemia’s
with a bone marrow biopsy
what did damesheck show us about treatments
you need to wipe out the bone marrow for leukemia patients. And use the 7+3 anthracylcine and cytarabine.
what is the exception for treating leukemia
CML BCR ABL use imatinib
what is AML induction support
propylactic antibiotics, antiemitics, hepa rooms, no raw berries or veggies grown in dirt no sick visitors,
what is the most common trans location of APL
15-17 use trans-retinoic acid will put the cancer into remission but then give them the 7+3 often have DIC.
