Acute Leukemia

Question 1

Leukemic

Answer 1

Abnormal increase of white blood cells

Question 2

Acute Leukemia characterized

Answer 2

by increase of white blood cells and decrease of other blood cells

Question 3

Anemia Definition

Answer 3

Lack of healthy red blood cells

Question 4

thrombocytopenia Definition

Answer 4

Deficiency of platelets causing bruising and bleeding

Question 5

Neutrophil definition

Answer 5

able to be stained by dye (usually white blood cells)

Question 6

Granulocytophenia?

Answer 6

Marked decrease of granulocytes

Question 7

Granulocyte?

Answer 7

White blood cells that are differentiated

Question 8

Cytopenia

Answer 8

Low blood cell (red and white) count

Question 9

Pancytopenia

Answer 9

Low counts of three components of blood: red blood cells, white blood cells, platelets

Question 10

4 essentials of diagnosis of Acute Leukemia

Answer 10

1) Short duration of sx: bleeding, fatigue, fever
2) (Pan)cytopenia
3) More than 20% blasts in bone marrow
4) Blasts in 90% of patient’s peripheral

Question 11

Most common malignant disease in children?

Answer 11

Acute leukemia (25% of cases)

Question 12

Type of acute leukemia in children?

Answer 12

ALL (Acute Lymphoblastic leukemia)

Question 13

Type of acute leukemia in adults?

Answer 13

AML (Acute Myelogenous leukemia)

Question 14

3 main etiologies

Answer 14

1) radiation
2) Benzene exposure
3) Chemotherapeutic agents

Question 15

Bloom’s Syndrome

Answer 15

Hereditary (mostly jewish) trait associated with AML. Cutaneous abnormalities.

Question 16

Fanconi’s Aplasia

Answer 16

Recessive disease with many chromosomal issues.

AML develops

Question 17

Down’s syndrome

Answer 17

Increased risk of AML and ALL

Question 18

Bone pain more common in

Answer 18

ALL

Question 19

Most common sx

Answer 19

fatigue and weakness

Question 20

Common signs

Answer 20

Pallor
Petechia
Purpura

Question 21

Sternal tenderness to palpation, lymphadenopathy, and hepatosplenomegaly are much
more common in

Answer 21

AML

Question 22

CNS leukemia more common in

Answer 22

ALL

Question 23

2 Most common Lab tests

Answer 23

1. CBC (Complete Blood count)

2. Marrow aspirate and biopsy

Question 24

Does staging exist for Acute Leukemia?

Answer 24

No.

Question 25

Complete remission rate?

Answer 25

70% in people younger than 60