Acute Kidney Injury & Chronic Kidney Disease (Ch. 34)-- Term First Flashcards

1
Q

Intrarenal AKI

A
  • Structural damage within kidney
    • Glomeruli
    • Vessels
    • Tubules
    • Interstitium
  • Sudden ⇣ in renal blood flowAcute tubular necrosis
    • Prerenal injury
    • Intratubular obstruction
    • Acute renal disease
    • Drug nephrotoxicity
    • Toxins from infections
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2
Q

Intrarenal AKI Clinical Manifestations

A
  • Initiation
    • No S/S for hrs. or days
    • ⇣ GFR
    • BUN
  • Maintenance
    • 1-2 weeks
    • Oliguria + ⇣ GFR
      • <20 mL/hr
    • Metabolic waste accumulation
      • Edema
      • Pulmonary congestion
      • HTN
      • Uremia
  • Recovery
    • Repair of renal tissue
    • Excessive diuresis
      • 1-2 L/day
      • First sign
    • ⇡ GFR & urinary output
    • ⇣ SCr & BUN
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3
Q

Prerenal AKI

A
  • Most common
    • 25-80% mortality rate
  • Sudden ⇣ in renal blood flowIschemic tubular necrosis
    • ⇣ GFR (<25% of normal)
      • Normal GFR: 120-130 mL/min
    • Sharp ⇣ urine output
      • Acute, early sign
    • ⇡ BUN : SCr
      • 10:1 (normal) → 20:1 (elevated)
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4
Q

CKD Metabolism Manifestations

A
  • Kidneys unable to excrete phosphorus
    • ⇡ Phosphorus & ⇣ Ca2+ → ⇡ PTH⇡ Ca2+ resorption from bone
  • Impaired Vit. D Synthesis
    • ⇣ Vit. D → ⇡ PTH & ⇣ Ca2+ intestinal absorption
      • Osteoporosis
      • Osteomalacia
      • ⇡ Fracture risk
  • Protein, CHO, & Fat metabolic changes
    • ⇣ Serum protein → ⇣ Muscle mass & ⇣ Colloidal osmotic pressure → Edema
    • Insulin resistance & glucose intolerance → DM
    • Dyslipidemia
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5
Q

CKD Fluid & Electrolyte Manifestations

A
  • Loss of ability to regulate Na+
    • Early CKD: Na+ & H2O loss
    • Late CKD: Na+ & H2O retention → Edema & HTN
  • 90% of K+ renally eliminated
    • ⇡ Hyperkalemia risk → Dysrhythmias
      • Dialysis (@ least 4 hrs.)
  • Ability to eliminate H+ & resorb HCO3-
    • Metabolic acidosis
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6
Q

Chronic Kidney Disease (CKD)

A

End result of kidney damage, develops slowlyIRREPARABLE

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7
Q

CKD Cardiovascular Manifestations

A
  • ⇡ Morbidity (illness) and mortality (death)
    • 10-20X higher
  • ⇡ Blood volume → HTN
  • Dyslipidemia → Vascular disease
    • Ischemic heart disease
    • HF
    • Stroke
    • Peripheral vascular disease
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8
Q

CKD Hematologic Manifestations

A
  • Anemia
    • ⇣ Erythropoiesis → Iron deficiency & ⇣ RBCs
      • Weakness, fatigue, HA, irritability, depression, insomnia, cognitive function
    • ⇣ Blood viscosity → ⇡ HR & Peripheral vasodilation
    • ⇣ Myocardial O2 → Angina, ischemic cardiac events
  • Dialysis damages platelets
    • ⇣ or impaired platelets → bleeding
    • ⇡ Risk of thrombotic disorders
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9
Q

Renal Failure

A
  • Kidneys fail to
    • Remove metabolic waste from the blood
    • Regulate fluid, electrolyte, & pH balance of ECF
  • Loss of endocrine function
    • Renin
    • Erythropoietin
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10
Q

Postrenal AKI

A
  • Bilateral urinary tract obstruction
    • Ureter
    • Bladder
    • Urethra
  • Retrograde pressure
    • Glomeruli
    • Tubules
    • Nephron
  • BPH– most common cause
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11
Q

CKD Pulmonary Manifestations

A
  • ⇡ Blood volume → Pulmonary edema & HTN
  • Kussmaul respirations
    • Hyperventilation
    • Compensatory mechanism for metabolic acidosis
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12
Q

Types of Acute Kidney Injury (AKI)

A
  • Prerenal
    • Blood flow to and through kidneys
  • Intrarenal
    • Structural damage
  • Postrenal
    • Obstruction to urine outflow
      • BPH (most common)
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13
Q

Acute Kidney Injury (AKI)

A

Abrupt injury to the kidneys, w/i 48 hrs.– REVERSIBLE (if treated early)

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14
Q

Chronic Kidney Disease Management

A
  • Dietary restrictions
    • ⇣ Protein, Na+, K+ & Phosphate
    • Vit. D supplementation
    • Fluid balance/restriction
    • Glucose control (DM)
  • Medications
    • ACE-Is & ARBs
      • Dilate efferent arteriole
  • End-stage renal failure
    • Renal replacement therapy
      • Peritoneal dialysis
      • Hemodialysis
    • Kidney transplant
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15
Q

Prerenal AKI Causes

A
  • Shock
    • Hypovolemia
  • HF w/ ⇣ CO
  • Intrarenal vasoconstriction
    • Contrast media
    • Cyclosporine
    • NSAIDS
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16
Q

Other CKD Manifestations

A
  • Altered immune function
    • ⇡ Infection risk
  • Altered CNS & PNS Function
    • Peripheral neuropathy
    • Restless leg syndrome
    • Uremic encephalopathy
  • Sexual dysfunction
    • Impotence
    • Hypofertility
    • Dysmenorrhea
  • Disorders of skin integrity
    • Pale, sallow, grey skin
    • Dry/scaly skin and mucous membranes
    • Bruising
17
Q

Chronic Kidney Disease (CKD) Clinical Manifestations

A

Multiple systemic effects related to loss of GFR and endocrine functions

  • ⇣ Kidney function
    • ⇣ GFR
      • <60 mL/min for 3 months +
    • Ion, electrolyte, and H2O resorption
    • Endocrine functions
  • Azotemia (nitrogenous waste in blood)
    • ⇡ BUN & ⇡ SCr
  • Uremia (urine in blood)
    • ⅔ of Nephrons destroyed
    • Uremic encephalopathy
      • Pruritis
      • N/V
      • Weakness/fatigue
    • ⇡ BP
    • ⇣ Erythropoiesis
    • Impaired Vit. D synthesis