Acute Kidney Injury & Chronic Kidney Disease (Ch. 34)-- Term First Flashcards
1
Q
Intrarenal AKI
A
-
Structural damage within kidney
- Glomeruli
- Vessels
- Tubules
- Interstitium
-
Sudden ⇣ in renal blood flow → Acute tubular necrosis
- Prerenal injury
- Intratubular obstruction
- Acute renal disease
- Drug nephrotoxicity
- Toxins from infections
2
Q
Intrarenal AKI Clinical Manifestations
A
-
Initiation
- No S/S for hrs. or days
- ⇣ GFR
- ⇡ BUN
-
Maintenance
- 1-2 weeks
-
Oliguria + ⇣ GFR
- <20 mL/hr
- Metabolic waste accumulation
- Edema
- Pulmonary congestion
- HTN
- Uremia
-
Recovery
- Repair of renal tissue
-
Excessive diuresis
- 1-2 L/day
- First sign
- ⇡ GFR & urinary output
- ⇣ SCr & BUN
3
Q
Prerenal AKI
A
- Most common
- 25-80% mortality rate
-
Sudden ⇣ in renal blood flow → Ischemic tubular necrosis
-
⇣ GFR (<25% of normal)
- Normal GFR: 120-130 mL/min
-
Sharp ⇣ urine output
- Acute, early sign
-
⇡ BUN : SCr
- 10:1 (normal) → 20:1 (elevated)
-
⇣ GFR (<25% of normal)
4
Q
CKD Metabolism Manifestations
A
- Kidneys unable to excrete phosphorus
- ⇡ Phosphorus & ⇣ Ca2+ → ⇡ PTH → ⇡ Ca2+ resorption from bone
-
Impaired Vit. D Synthesis
-
⇣ Vit. D → ⇡ PTH & ⇣ Ca2+ intestinal absorption
- Osteoporosis
- Osteomalacia
- ⇡ Fracture risk
-
⇣ Vit. D → ⇡ PTH & ⇣ Ca2+ intestinal absorption
-
Protein, CHO, & Fat metabolic changes
- ⇣ Serum protein → ⇣ Muscle mass & ⇣ Colloidal osmotic pressure → Edema
- Insulin resistance & glucose intolerance → DM
- Dyslipidemia
5
Q
CKD Fluid & Electrolyte Manifestations
A
- Loss of ability to regulate Na+
- Early CKD: Na+ & H2O loss
- Late CKD: Na+ & H2O retention → Edema & HTN
- 90% of K+ renally eliminated
-
⇡ Hyperkalemia risk → Dysrhythmias
- Dialysis (@ least 4 hrs.)
-
⇡ Hyperkalemia risk → Dysrhythmias
-
⇣ Ability to eliminate H+ & resorb HCO3-
- Metabolic acidosis
6
Q
Chronic Kidney Disease (CKD)
A
End result of kidney damage, develops slowly– IRREPARABLE
7
Q
CKD Cardiovascular Manifestations
A
- ⇡ Morbidity (illness) and mortality (death)
- 10-20X higher
- ⇡ Blood volume → HTN
- Dyslipidemia → Vascular disease
- Ischemic heart disease
- HF
- Stroke
- Peripheral vascular disease
8
Q
CKD Hematologic Manifestations
A
- Anemia
-
⇣ Erythropoiesis → Iron deficiency & ⇣ RBCs
- Weakness, fatigue, HA, irritability, depression, insomnia, ⇣ cognitive function
- ⇣ Blood viscosity → ⇡ HR & Peripheral vasodilation
- ⇣ Myocardial O2 → Angina, ischemic cardiac events
-
⇣ Erythropoiesis → Iron deficiency & ⇣ RBCs
-
Dialysis damages platelets
- ⇣ or impaired platelets → bleeding
- ⇡ Risk of thrombotic disorders
9
Q
Renal Failure
A
- Kidneys fail to
- Remove metabolic waste from the blood
- Regulate fluid, electrolyte, & pH balance of ECF
-
Loss of endocrine function
- Renin
- Erythropoietin
10
Q
Postrenal AKI
A
-
Bilateral urinary tract obstruction
- Ureter
- Bladder
- Urethra
-
Retrograde pressure
- Glomeruli
- Tubules
- Nephron
- BPH– most common cause
11
Q
CKD Pulmonary Manifestations
A
- ⇡ Blood volume → Pulmonary edema & HTN
-
Kussmaul respirations
- Hyperventilation
- Compensatory mechanism for metabolic acidosis
12
Q
Types of Acute Kidney Injury (AKI)
A
-
Prerenal
- ⇣ Blood flow to and through kidneys
-
Intrarenal
- Structural damage
-
Postrenal
- Obstruction to urine outflow
- BPH (most common)
- Obstruction to urine outflow
13
Q
Acute Kidney Injury (AKI)
A
Abrupt injury to the kidneys, w/i 48 hrs.– REVERSIBLE (if treated early)
14
Q
Chronic Kidney Disease Management
A
- Dietary restrictions
- ⇣ Protein, Na+, K+ & Phosphate
- Vit. D supplementation
- Fluid balance/restriction
- Glucose control (DM)
- Medications
-
ACE-Is & ARBs
- Dilate efferent arteriole
-
ACE-Is & ARBs
- End-stage renal failure
- Renal replacement therapy
- Peritoneal dialysis
- Hemodialysis
- Kidney transplant
- Renal replacement therapy
15
Q
Prerenal AKI Causes
A
- Shock
- Hypovolemia
- HF w/ ⇣ CO
-
Intrarenal vasoconstriction
- Contrast media
- Cyclosporine
- NSAIDS