Acute Kidney Injury

Question 1

What investigations should be ordered in assessment of AKI?

Answer 1

Creatinine, urea, calcium, CK, protein electrophoresis (if appropriate), MSU microscopy, renal tract US

Question 2

What is the use of normal saline associated with?

Answer 2

hyperchloraemic metabolic acidosis

Question 3

What is I5HP?

Answer 3

a short interfering RNA which reduces p53 in renal tubular cells - shown to reduce AKI after cardiac surgery

Question 4

What are the principles of treatment of AKI?

Answer 4

remove causes/exacerbating factors, manage fluids, mange hyperkalaemia/acidosis, RRT as required, stress ulcer prophylaxis, modify medication dosing

Question 5

How can contrast induced AKI be prevented?

Answer 5

pre hydration, minimise contrast volume, discontinue nephrotoxins

Question 6

What is the treatment for hepatorenal syndrome?

Answer 6

terlipressin

Question 7

What is the treatment for rhabdomyolysis?

Answer 7

early aggressive fluids, ?IV bicarb, ?mannitol