Acute Kidney Injury

Question 1

Drugs to stop in AKI

Answer 1

Stop the DAMN drugs

Diuretics: thiazide and loop
ACE-i/ ARB
Metformin (stop if eGFR <30, consider if 30-45)
NSAIDs/ Nephrotoxic (aminoglycosides - gentamicin)
Others: lithium, digoxin

Continue: statin, aspirin 75mg, Betablockers (unless hypotensive)

Question 2

Stages

Answer 2

Stage 1: creatinine rise of 1.5x compared to baseline or urine output <0.5 ml/kg/hour for 6 hours

Stage 2: creatinine rise of 2x compared to baseline or urine output <0.5 ml/kg/hour for 12 hours

Stage 3: creatinine rise of 3x compared to baseline or urine output <0.3 ml/kg/hour for 24 hours (or anuria for 12 hours)