acute kidney injury Flashcards
definition of AKI
inability of kidney to maintain homeostasis leading got a buildup of nitrogenous wastes
AKI characteristics
occurs over hours to days, there is increased baseline creatinine of more than 50%. decreased Cr clearance of more than 50% deterioration requiring dialysis.
anuria
less than 100mL/24
oliguria
<500mL
polyuria
> 2.5L
most common form of AKi
prerenal or functional
if it is intrarenal what is the next step?
considering whether it is tubulointerstitial or glomerular.
prerenal causes
inadequate perfusion, need to check volume status
renal causes
this is despite perfusion and excretion. check urinalysis, full blood count, and autoimmune screen
post-renal causes
blocked outflow. check the bladder and catheter and ultrasound
types of intrinsic AKI
ATN (ischemia, toxin, tubular factors), AIN (inflammation, edema), glomerulonephritis (damage to the filtering mechanisms, depends on the presentation)
post-renal causes
BPH, malignancy, blocked catheter, ureter
what dilates the afferent arteriole?
prostacyclin and NO.
this is why NSAIDs block the afferent dilation of auto regulatory
what constricts the afferent arteriolar
endothelin, catecholamines, thromboxane
what constricts the efferent arteriole
angiotensin II
thus ACEi block this
what are the classifications of ATN
nephrotoxic, ischemic
nephrotoxic ATN endogenous toxins
heme pigments (myoglobin and hemoglobin) myeloma light chains.
exogenous toxins nephro ATN
antibiotics (aminoglycosides), radioconstrast agents , heavy metals. poisons such as ethylene glycol
what are the phases of ATN
insult, oliguria, dialysis, polyuria, and recovery. the creatinine increases steadily and then decreases
causes of acute interstitial nephritis
allergic interstitial nephritis, due to hypersensitivity to drugs; infections from bacteria and viruses, sarcoidosis