Acute inflammation Flashcards
1
Q
What are the 4 stages of leukocyte emigration? Which cellular apparatus is responsible for each stage?
A
1) Margination- Stasis and loss of axial streaming
2) Rolling- Transient and weak binding by selectins
3) Adhesion- Firm adhesion to endothelium by integrins
4) Transmigration- Movement into extravascular space via pecam-1 and cd31
2
Q
What are the 3 stages to phagocytosis?
A
1) Recognition and attachment of particle to leukocyte via opsonins
2) Engulfment due to pseudopods surrounding particle and formation of phagocytic vacuole
3) Production of ROS’ and lysosomal enzymes
3
Q
Which diseases attract lymphocytes rather than neutrophils?
A
Viral hep a b c
Meningitis
Myocarditis
4
Q
What is the classical morphology of neutrophils?
A
Polymorphic granular cells
