Acute Inflammation

Question 1

What are the five cardinal symptoms of inflammation?

Answer 1

1. Rubor
2. Calor
3. Tumor
4. Dolor
5. Functio laesa

Question 2

What are two prerequisites for a tissue to become inflamed.

Answer 2

Must be living and vascularized

Question 3

Which cells make and store histamine?

Answer 3

Mast cells

Question 4

What does histamine do?

Answer 4

Venodilation and increased vascular permeability, endothelial activation

Question 5

What two things can bind to mast cell to provoke degranulation?

Answer 5

IgE crosslinking and C3a or C5a binding.

Question 6

What cells make and store serotonin?

Answer 6

Platelets

Question 7

What does serotonin do?

Answer 7

Venodilation and increased vascular permeability, endothelial activation

Question 8

Which cells make Nitric Oxide?

Answer 8

Endothelial cells and infiltrating lymphocytes in inflamed tissues.

Question 9

What does nitric oxide do?

Answer 9

Smooth muscle relaxation

Question 10

What does bradykinin do?

Answer 10

Vasodilation and pain

Question 11

What drugs inhibit COX1?

Answer 11

Non-specific NSAIDs

Question 12

What drugs inhibit COX2?

Answer 12

Specific and non-specific NSAIDs

Question 13

What drug class inhibits PLA2?

Answer 13

Corticosteroids

Question 14

Which cyclooxygenase is inducible?

Answer 14

COX2

Question 15

What cells make platelet activating factor and what does it do?

Answer 15

Neutrophils, basophils, monocytes, macrophages, endothelial cells, platelets. Does pretty much the same thing as histamine.

Question 16

Is PAF more potent than histamine?

Answer 16

Yes, by 10,000 fold!

Question 17

Which cells make IL-8? Where do they store the granules?

Answer 17

Endothelial cells store them in Wiebel Palade bodies.