Acute Inflammation Flashcards
1
Q
TLR’s
A
-Part of innate and adaptive immune response recognize PAMP’s.
2
Q
NF-KB
A
-Transcription factor downstream of TLR’s turns on pro-inlammatory genes
3
Q
CD-14
A
-TLR on macrophages that responds to LPS on gram negative bacterial cell Surfaces
4
Q
Arachadonic Acid
A
-Cleaved by PLA2, inhibited by steroids
5
Q
COX Pathway
A
- PGE2, PGD2, PGI2
- Causes Vasodilation at Arteriole and increased permiability at venule
- Pain and fever
6
Q
5-Lipo Oxygenase Pathway
A
- C4,D4,E4 also B4
- Constriction and spasm of smooth muscle, increased permeability but vaso and broncho constriction.
- Generated by mast cell and responsible for maintaining acute inflammation
7
Q
LTB4
A
-Attracts Neutrophils
8
Q
Attract Neutrophils
A
- C3a, C5a
- LTB4
- IL-8
- Bacterial Products
9
Q
Mast Cells
A
- Degranulate in response to IgE crosslinking, C3a and C5a, Trauma
- Release of Histamine
- Release of Leukotrienes (5-Lipo Oxygenase) to maintain the immune response
10
Q
Histamine
A
-Vasodilation and Increased vascular permiability, released from mast cells
11
Q
Complement
A
- C3 Convertase
- C5 Convertase
- MAC
12
Q
Classical Pathway
A
-Activation upon Ag binding to IgM or IgG
13
Q
Alternative Pathway
A
-Activated upon attachment to bacterial products
14
Q
MBL Pathway
A
-Mannose Binding lectin binds mannose on the surface of bacteria and stabalizes comlement
15
Q
C3
A
- C3a is proinflammatory molecule and activator of mast cells
- C3b joins to form a C5 convertase and is a powerful opsin
