Acute Drug Abuse - Dr. C Flashcards
In the liver, alcohol (ethanol) is converted to _____ through alcohol dehydrogenase.
Acetaldehyde
In the liver, alcohol is converted to acetaldehyde and then to acetate by this enzyme.
Acetaldehyde dehydrogenase
True or False: The acetate formed from alcohol will go into the TCA cycle (Krebs cycle) to form ATP, which is why alcohol has a significant caloric value.
True
How does disulfiram (antabuse) work?
It blocks acetaldehyde dehydrogenase, which results in accumulation of acetaldehyde, which is why you get terrible feeling with the “antabuse reaction”.
Can breathalyzer testing results be used in court?
No, but BAC can be.
______ is a metabolite of alcohol that can be found in urine even 2-3 days after someone has been drinking and is mainly used in outpatient monitoring therapy.
Ethyl glucuronide
Flumazenil is a reversal agent for overdose on ______.
Benzodiazepines
Is there a reversal agent for barbiturates?
No
Rohypnol (flunitrazepam) and GHB are forms of benzodiazepines.
FALSE! Rohypnol is but GHB is nothing like it even though they are both date rape drugs.
True or False: There is endogenous GHB in all of us.
True
True or False: It is difficult to prove someone gave another person GHB because everyone has endogenous GHB and can vary from person to person.
True
According to Dr. C’s lecture, what is the main date rape drug?
Ethanol
True or False: Cocaine is a natural versatile drug and comes in many formulations, including chewing the leaves, smoking the paste. snorted or IV administration of the powder, or smoking the free base of it, which is crack.
True
The active moiety in marijuana is _____.
THC
THC has 2 levels, low dose, which is ethanol-like, and high dose, which is LSD-like. Which is more common?
Low-dose
