Acute Coronary Syndrome Flashcards

1
Q

ESSENCE

A

Usually result of thrombus from atherosclerotic plaque blocking a coronary artery, this thrombus is is mostly made of platelets

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2
Q

3 types of acute coronary syndrome

A
  • Unstable angina
  • ST elevation myocardial infarction (STEMI)
  • Non-ST elevated myocardial infarction (NSTEMI)
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3
Q

INVESTIGATIONS

First line

A
  • 1) ECG - if ST elevation diagnosis is STEMI
  • 2) Tropnonin blood tests - if raised or ECG changed diagnosis is NSTEMI, if normal and ECG unchanged then unstable angina
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4
Q

INVESTIGATIONS

Other investigations

A
  • Chest x-ray - investigate other causes of pain
  • ECHO - assess functional damage
  • CT coronary angiogram - assess for coronary artery disease
  • FBC
  • U&Es
  • LFT
  • Lipid profile
  • TFT
  • HbA1c and fasting glucose
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5
Q

CLINICAL FEATURES

Symptoms

A
  • Central, constricting chest pain associated with
    • Nausea and vomiting
    • Sweating and clamminess
    • Feeling of impending doom
    • Shortness of breath
    • Palpitations
    • Pain radiating to jaw or arms
  • Lasts for 20 minutes after rest
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6
Q

AETIOLOGY

Risk factors

A
  • Diabetes
  • Hyperlipidaemia
  • Hypertension
  • Metabolic syndrome
  • Renal impairment
  • Peripheral arterial disease
  • History of ischaemic heart disease
  • Obesity
  • Age
  • Smoking
  • Cocaine use
  • Physical inactivity
  • Family history
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7
Q

INVESTIGATION

ECG changes in STEMI

A
  • ST segment elevation
  • New left bundle branch block
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8
Q

INVESTIGATION

ECG changes in NSTEMI

A
  • ST segment depression
  • Deep T wave inversion
  • Pathological Q waves
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9
Q

Left coronary artery - heart area and ECG leads

A

Area - anterolateral

ECG leads - I, aVL, V3-6

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10
Q

Left anterior descending - heart area and ECG leads

A

Area - anterior

ECG leads - V1-4

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11
Q

Circumflex - heart area and leads

A

Area - lateral

Leads - I, aVL, V5-6

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12
Q

Right coronary artery - heart area and ECG leads

A

Area - inferior

Leads - II, III, aVF

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13
Q

Other causes of raised troponins

A
  • Chronic renal failure
  • Sepsis
  • Myocarditis
  • Aortic dissection
  • Pulmonary embolism
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14
Q

What are troponins

A

Proteins found in cardiac muscle, released when muscle is ischaemic

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15
Q

MANAGEMENT

Acute STEMI treatment

A
  • Primary PCI (if within 2 hours presentation)
  • Thrombolysis (if PCI not available within 2 hours presentation)
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16
Q

Thrombolysis mechanism

A

Injecting a fibrinolytic medication breaks down fibrin and dissolves clots, significant risk of bleeding

17
Q

MANAGEMENT

Acute NSTEMI treatment

A
  • Remember BATMAN
    • Beta-blockers unless contraindicated
    • Aspirin 300mg stat dose
    • Ticagrelor 180mg stat dose (or clipidogrel if higher bleed risk)
    • Morphine titrated to control pain
    • Anticoagulant (Fondaparinux)
    • Nitrates (GTN)
  • Give oxygen only if saturations dropping <95%
18
Q

Score used to assess for PCI in NSTEMI

A
  • GRACE score
    • Gives 6 month risk of death or repeat MI after having NSTEMI
    • <5% low risk
    • 5-10% medium risk
    • >10% high risk
  • If medium or high then considered for early PCI to treat underlying artery disease
19
Q

COMPLICATIONS

Of MI

A
  • Remember DREAD
    • Death
    • Rupture of heart septum or papillary muscles
    • Edema (heart failure)
    • Arrhythmia and aneurysm
    • Dressler’s syndrome
20
Q

MANAGEMENT

Secondary prevention

A
  • Medical (6As)
    • Aspirin 75mg once daily
    • Another antiplatelet (clopidogrel or ticagrelor for 12 months)
    • Atorvastatin 80mg
    • ACE inhibitor (ramipril)
    • Atenolol (or other beta blocker)
    • Aldosterone antagonist for those with heart failure
  • Lifestyle
    • Stop smoking
    • Reduce alcohol
    • Exercise
    • Diet
21
Q

Types of MI

A
  1. Traditional due to acute coronary event
  2. Ischaemia secondary to increased deman or supply of oxygen (such as anaemia, tachycardia or hypotension)
  3. Sudden cardiac death or arrest suggestive of ischaemic event
  4. Associated with PCI/coronary stunting/CABG