Acute/Chronic Pancreatitis, Celiac Disease Flashcards
Acute pancreatitis tx requires…
it is managed similar to…
early & aggressive IV fluids
pts with sepsis
In pts with inflammatory episode of acute pancreatitis, sxs are related to…
intrapancreatic activation of enzymes with pain, nausea and vomiting, and associated intestinal ileus
Causes for acute pancreatitis?
Alcohol
Gallstones
Trauma/surgery
acute DC of meds for DM/hyperlipidemia
s/p ERCP
Analgesic tx of acute pancreatitis?
Hydromorphine
Fentanyl
Morphine
AVOID Demerol
Abx for acute pancreatitis?
Prophylaxis no longer recommended
Pts with ascending cholangitis/necrotizing pancreatitis: Beta lactam/beta lactamase inhibitor
PEN all: Levofloxacin
acute pancreatitis tx on DC?
dietary modification to reduce dietary fats, alcohol, and added sugars
What is chronic pancreatitis?
8
Hallmark comps of chronic pancreatitis?
8
Primary tx for malabsorption secondary to chronic pancreatitis?
8
Tx of chronic pancreatitis?
pancreatic enzyme supplements
antisecretory agent
Analgesics
Corticosteroids for autoimmune pancreatitis
When should pancreatic enzymes be administered?
during or just after meals
Pancreatic enzymes are primarily used to tx…
malabsorption associated with chronic pancreatitis they
also used to tx pain
Role of proteases in pancreatic enzyme supplements?
act as substitutes for endogenous trypsin, leading to a decrease in CCK release
What is celiac disease?
Autoimmune condition
Immune-mediated reaction to dietary gluten: found in wheat, barley, rye
Affects small intestine
Immunologic cross-reactivity, inflammation, and tissue damage (villous atrophy) with subsequent malabsorption
Who is predisposed to celiac disease?
individuals–Homogenicity for HLA-DQ2/DQ8
