Acute Care and Trauma (1) Flashcards
What is acute kidney injury (AKI)?
An acute decline in kidney function, leading to a rise in serum creatinine and/or a fall in urine output
What is the aetiology of acute kidney injury (AKI)?
Pre-renal, renal and post renal
AKI may be due to various insults such as:
- impaired kidney perfusion
- exposure to nephrotoxins
- outflow obstruction
- intrinsic kidney disease
What are the risk factors of acute kidney injury (AKI)?
Advanced age
Underlying kidney disease
DM
Sepsis: may result in ATN, pre-kidney AKI from hypotension
Nephrotoxins e.g. aminoglycosides, NSAIDs, vancomycin
What are the pre-renal causes of an AKI?
Reduced renal perfusion:
1. Shock (hypovolaemic, septic, cardiogenic)
2. Hepatorenal syndrome (liver failure)
What are the renal causes of an AKI?
- Acute tubular necrosis: ischaemia, drugs and toxins
- Acute glomerulonephritis
- Acute interstitial nephritis: NSAIDs, penicillins, sulphonamides
- Vessel obstruction:
- Renal artery/vein thrombosis
- Cholesterol emboli
- Vasculitis
Other causes: myeloma, haemolysis, nephropathy
What are the post renal causes of an AKI?
Stone
Tumour (pelvic, prostate, bladder)
Blood clots
Retroperitoneal fibrosis
What are the presenting symptoms of AKI?
Usually asymptomatic
Lower urinary tract symptoms:
- Urgency
- Frequency
- Hesitancy
Low urine output (oliguria)
Malaise
Anorexia
Nausea and vomiting
Pruritus (itching)
Drowsiness
Convulsions, coma (caused by uraemia)
What are the signs of acute kidney injury (AKI) on physical examination?
- Reduced urine output
- Pulmonary and peripheral oedema
- Arrhythmias (secondary to changes in potassium and acid-base balance)
- Features of uraemia (e.g. pericarditis or encephalopathy)
What are the appropriate investigations for AKI?
- U&Es: serum creatinine (rise of 26 micro mol/L in 48 hours or >50% in 7 days), potassium, sodium and urea
- Urinalysis: all suspected AKI patients, cellular casts (glomerulonephritis)
- Renal ultrasound: if no identifiable cause of deterioration or risk of obstruction
- ECG: changes associated with hyperkalaemia (tented T waves) and CXR
What is the management plan for AKI?
1.Assess hydration and fluid balance:
Pulse rate, lying and standing BP, JVP, skin turgor, chest auscultation, peripheral oedema, central venous pressure, fluid and weight charts. ECG monitoring (hyperkalaemia)
- If hypovolaemic (+ hyperkalaemia)
- fluid resuscitation
- review medications and stop nephrotoxins
- identify and treat underlying cause
others:
- vasoactive drug
- blood transfusion - If hypervolaemic (+ pulmonary oedema and hyperkalaemia)
- loop diuretic (under specialist supervision) and sodium restriction
- identify and treat underlying cause
consider: renal replacement therapy
Metabolic acidosis (if pH < 7.2): 50–100 mL of 8.4% bicarbonate via central line over 15–30 min
What medications can cause an AKI?
Acute tubular necrosis (ATN):
- Paracetamol
- Aminoglycosides
- Amphotericin B (anti-fungal)
- NSAIDs
- ACE-inhibtors
- Lithium
Acute interstitial nephritis:
- NSAIDs
- Penicillins
- Sulphonamides
Others: opioids, other antibiotics e.g. trimethoprim, vancomycin
What is the treatment for acute pulmonary oedema?
P- positioning (sit up)
O- oxygen
D- diuretic (furosemide) and fluid restriction
M- (dia)morphine
A- anti-emetics
N- nitrates (GTN infusion if SBP >110, or 2 puffs GTN spray if SBP >90)
What are the possible complications of acute kidney injury (AKI)?
Common and life-threatening:
- Hyperkalaemia
- Sepsis
- Metabolic acidosis
- Pulmonary oedema
- Hypertension
Less common:
Gastric ulceration, bleeding (platelet dysfunction), muscle wasting (hypercatabolic state), uraemic pericarditis, uraemic encephalopathy, acute cortical necrosis
What is acute respiratory distress syndrome?
A syndrome of acute and persistent lung inflammation with increased vascular permeability
What are the causes of acute respiratory distress syndrome?
(TOAST)
Transfusion
Overdose of drugs
Aspiration
Sepsis
Transplantation
(PIP)
Pneumonia
Injury/burns
Pancreatitis
What is ARDS characterised by?
A - Absence of raised capillary wedge pressure
R - Reduced blood oxygen (hypoxaemia)
D - Double-sided infiltrates (bilateral infiltrates)
S - sudden onset (acute- within 1 week)
What are the causes of ARDS?
Infection: sepsis, pneumonia
Massive blood transfusion
Trauma
Smoke inhalation
Acute pancreatitis
Covid-19
Cardio-pulmonary bypass
What is the aetiology of acute respiratory distress syndrome?
Severe insult to lungs
Inflammatory mediators released
Capillary permeability increases
Results in pulmonary oedema, reduced gas exchange and reduced lung compliance
(Injury, inflammation, increased permeability)
What are the pathological stages of ARDS?
Exudative
Proliferative
Fibrotic
What are the presenting symptoms of ARDS?
Rapid deterioration of respiratory function
Dyspnoea
Cough
Symptoms of cause
What are the signs of ARDS on physical examination?
Think SMURF: fast, blue, noisy:
Cyanosis
Tachypnoea
Tachycardia
Widespread crepitations
Hypoxia refractory to oxygen treatment
(Usually bilateral but may be asymmetrical in early stages)
What are the clinical features of ARDS?
Dyspnoea
Elevated respiratory rate
Bilateral lung crackles
Low oxygen saturations
What are the appropriate investigations for ARDS?
1st line:
CXR- bilateral infiltrates
ABG- low partial oxygen pressure
Sputum/ blood/ urine cultures- positive if underlying infection
Amylase- elevated in cases of acute pancreatitis
Others:
BNP- <100 nanograms/L make HF less likely, so ARDS more likely
Pulmonary artery catheterisation- Pulmonary artery occlusion pressure (PAOP) ≤18 mmHg suggests ARDS
What are the two key investigations for ARDS?
Chest x-ray and ABG