Acute bronchitis, influenza and TB Flashcards
What is bronchitis
inflammation of the large airways of the lungs
Common causes of bronchitis
VIRUS
- influenza A and B
- parainfluenza
- RSV
- coronavirus
- rhinovirus
- adenovirus
Clinical manifestations of acute bronchitis
- persistent cough for 1 to 3 weeks
- with or without sputum
- low grade fever
- wheezing, mild dyspnea
- rhonchi that clears with cough
- chest pain
Why do you do a CXR if bronchitis is suspected
to rule out pneumonia
Indications for a chest xray with bronchitis
- tachycardia/tachypnea
- fever
- hypoxia
- dementia
- rales,egophany, tactile fremitus
- MS change in pts >75
When is bronchitis suspected in a patient
persistent cough for at least 5 days
What is procalcitonin
blood test used to detect a bacterial infection
What procalcitonin levels would you consider using antibiotics
> 0.25 mcg/L
OTC cough med for bronchitis
- Dextromethorphan (cough suppressant)
- guaifenesin (expectorant)
Management of bronchitis
- patient education
- bronchodilators
- antitussives
Perscription cough medications for bronchitis
- robitussin AC (guaifenesin with codiene)
- tessalon pearles (benzonatate)
High risk populations for the flu
- pregnant women
- children
- > 65
- comorbities
How is influenza subtyped
surface hemagglutinin (H) and neuraminidase (N) antigens
How many different H antigens are there? N?
16 H
9 N
What three subtypes affect humans
H1, H2, H3, N1, N2
Antigenic shifts
major changes in the glycooproteins of H and N
What are antigenic shifts responsible for
pandemics and epidemics
Antigenic drifts
result from point mutations in the RNA gene segments
Clinical manifestation of influenza
- sudden onset
- headache
- fever
- myalgia
- cough
- sore throat
Rapid influenza antigen testing
- differentiates between types A and B
- nasopharyngeal swab
Immunifuorescence
- respiratory swab
- direct and indirect staining
- depends on laboratory expertise
- not often used
Reverse transcriptase polymerase chain reaction (RT-PCR)
- most sensitive and specific
- differentiates between types and subtypes
- get specimen through nasal swab, bronchial lavage, throat swab
Neuraminidase inhibitors for influenza
- zanaminvir
- oseltamivir
- peramivir
Adamantane agents for influenza
- amantadine
- rimantadine
*no longer recommended