Acute agitation (Drugs and management)

Question 1

What is the brand name for aripiprazole?

Answer 1

Abilify, generics

Question 2

What is the dosage of aripiprazole for psychosis?

Answer 2

10–15 mg/day PO

Question 3

What is the dosage of aripiprazole for mania when used as acute monotherapy?

Answer 3

15 mg/day PO

Question 4

What are common adverse effects of aripiprazole?

Answer 4

Akathisia/EPS, dizziness, orthostatic hypotension, headache, GI complaints, tremor, sedation.

Question 5

What drug interactions can decrease aripiprazole levels?

Answer 5

Carbamazepine, phenytoin, rifampin

Question 6

What drug interactions can increase aripiprazole levels?

Answer 6

Ketoconazole, quinidine, fluoxetine, paroxetine

Question 7

What is the brand name for olanzapine?

Answer 7

Zyprexa, Zyprexa Zydis, generics

Question 8

What is the dosage of olanzapine for delirium?

Answer 8

5–10 mg/day PO

Question 9

What are common adverse effects of olanzapine?

Answer 9

Anticholinergic effects, akathisia/EPS, dizziness, neuroleptic malignant syndrome, DRESS.

Question 10

What drug interactions are associated with olanzapine?

Answer 10

Additive sedation with CNS depressants; antagonism of dopamine agonists; may potentiate antihypertensive drug effects.

Question 11

What is the dosage of intramuscular olanzapine for delirium or mania?

Answer 11

2.5–10 mg IM; repeat in 2 h and 6 h PRN to a maximum of 30 mg/24 h

Question 12

What is the maximum dose of intramuscular olanzapine for debilitated patients?

Answer 12

2.5 mg/dose

Question 13

What is the brand name for quetiapine?

Answer 13

Seroquel, generics

Question 14

What is the dosage of quetiapine for psychosis?

Answer 14

300–800 mg/day PO

Question 15

What are common adverse effects of quetiapine?

Answer 15

Sedation, dizziness, akathisia/EPS, neuroleptic malignant syndrome.

Question 16

What is the brand name for risperidone?

Answer 16

Risperdal, generics

Question 17

What is the dosage of risperidone for psychosis?

Answer 17

2–8 mg/day PO

Question 18

What are common adverse effects of risperidone?

Answer 18

Akathisia/EPS, dizziness, neuroleptic malignant syndrome.

Question 19

What is the brand name for ziprasidone?

Answer 19

Zeldox, generics

Question 20

What is the starting dosage of ziprasidone for psychosis?

Answer 20

40 mg BID PO

Question 21

What are common adverse effects of ziprasidone?

Answer 21

Akathisia/EPS, insomnia; consider ECG to monitor QTc interval.

Question 22

What is the brand name for clonazepam?

Answer 22

Rivotril, generics

Question 23

What is the dosage of clonazepam for mania?

Answer 23

0.25–0.5 mg BID–TID PO

Question 24

What are common adverse effects of clonazepam?

Answer 24

Sedation, dizziness, cognitive impairment; rarely, respiratory depression.

Question 25

What is the brand name for lorazepam?

Answer 25

Ativan, generics

Question 26

What is the dosage of lorazepam for dementia? and what is the dosage for Mania/psychosis?

Answer 26

0.5–1 mg Q6–8H PO for dementia. ## Footnote 1-2mg PO/IM adjunctively with antipsychotics for Mania or psychosis.

Question 27

What are common adverse effects of lorazepam?

Answer 27

Sedation, dizziness, cognitive impairment; rarely, respiratory depression.

Question 28

What is the brand name for oxazepam?

Answer 28

generics

Question 29

What is the dosage of oxazepam for dementia?

Answer 29

10–15 mg TID PO

Question 30

What are common adverse effects of oxazepam?

Answer 30

Sedation, dizziness, cognitive impairment; rarely, respiratory depression.