ACS Drugs

Question 1

What is the mechanism of action of aspirin

Answer 1

Aspirin irreversibility and non-selectively binds to cyclooxygenase enzymes (COX-1 and COX-2) causing them to become inactivated

Inactivating COX1 results in the reduction of platelet thromboxane (TXA2) production, which causes a reduction in platelet aggregation and thrombus formation. It also results in the reduction of endothelial prostaglandin (PGI2) production. This results in a decrease in nociceptive sensitisation and inflammation.

Question 2

Aspirin irreversibility and non-selectively binds to which enzymes

Answer 2

Cyclooxygenase enzymes (COX-1 and COX-2)

Question 3

Inactivating COX1 results in the reduction of what?

Answer 3

Platelet thromboxane (TXA2) production

Question 4

Reduction in platelet thromboxane (TXA2) production causes what?

Answer 4

A reduction in platelet aggregation and thrombus formation