Acromegaly Flashcards
1
Q
What is acromegaly
A
Inc i n GH release from a pit tumour or hyperplasia or via ectopic GHRH from a carcinoid tumour
Associated with MEN-1
GH stimulates bone and soft tissue growth through the secretion of insulin-like GF
2
Q
Symptoms
A
Acroparasthesia Amenorrhoae Dec libido Headache Inc sweating Snoring arthralgia Backache Gloves shoes rings don’t fit
3
Q
Signs
A
Inc hand size, Jae, feetcarsening face wide nose Big supraorbital ridges Macroglossia Wide;y spaced teeth Puffy lips eyelids skin Scalp folds Skin darkening Acanthposis nigicans Laryngeal dyspnoea OSA Goitre Prox weaknesss and arthropathy Carpal tunnel Signs from pit mass
4
Q
The diagnostic test for Acromegaly is ?
A
The diagnostic test for Acromegaly is an oral glucose tolerance test with growth hormone measurements
Oral glucose tolerance test
In normal patients the GH is suppressed to <2mu/L with hyperglycaemia
In acromegaly there is no suppression of GH
May also demonstrate impaired glucose tolerance which is associated with acromegaly
Pituitary MRI to look for the tumour
5
Q
Tx
A
Ocretide somatostatin analogue
