Acromegaly Flashcards
1
Q
What is Acromegaly?
A
Symptoms from XS production of Growth Hormone.
2
Q
Pathology of Acromegaly?
A
Pituitary Tumor: XS Growth Hormone = XS IGF-1 = Symptoms/Complications
3
Q
Presentation of Acromegaly?
A
Overgrown features, Headache (Space-Occupying lesion) + Bitemporal Hemianopia
4
Q
Complications of Acromegaly?
A
ABCDEF Mnemonic Arithritis BP increased Carpal Tunnel Syndrome Diabetes Enlarged Organs Field effects (visual)
5
Q
Investigations for Acromegaly?
A
1) IGF-1: raised
2) Oral glucose tolerance test: fail to suppress IGF-1 <1 = diagnosis
3) MRI of pituitary/hypothalamus
6
Q
Management of Acromegaly?
A
1) Trans-sphenoidal excision
2) GH inhibition - octreotide (somatostatin antagonist)
3) GH receptor antagonist - pegvisomant
4) Radiotherapy
