acromegalia Flashcards

1
Q

de que es consecuncia la hipersecrecion de Gh

A

adenoma somatotropico

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2
Q

que secretan los adenomas de celulas madre acidofilas

A

GH y PRL

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3
Q

tumores que producen Gh

A

pancreatico
ovarico
pulmonar
hematopoyetica

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4
Q

causa mas comun de acromegalia mediada por GHRH

A

tumor carcinoide en el torax o el abdomen

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5
Q

Dx de acromegalia

A

demostrar ineficacia de la supresion de GH a menos de 0.4 microgramos/L en termino de 1-2 horas de una carga de glucosa oral

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6
Q

Tx primario de eleccion para micro t macroadenomas

A

ablacion quirurgica transesfenoidal

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7
Q

Tx secundario de adenomas de G

A

acetato d octreotido y lanreotido analogo de la somatostatina que actua en los receptores SSTR2 y SSTR5

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8
Q

mecanismo de accion de psgvisomant

A

antagonista de la ccion de GH endogena al bloquear la union periferica de la hormona a su receptor

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9
Q

ultima linea de tratamiento de adenoma productor de GH

A

cabergolina

bromocriptina

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