Acquired Bleeding Disordres Flashcards

1
Q

What are the major Acquired bleeding disorders?

A

1) Thrombocytopenia
2) Liver Failure
3) Drugs
4) Haemorrhagic Disease of Newborn

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2
Q

How would you spot someone who’s thrombocytopenic?

A

Petechia
Ecchymosis
Mucosal bleeding
Rarely a CNS bleed

Then FBC

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3
Q

What are the major causes of thrombocytopenia?

A

Marrow failure or infiltration

ITP, DIC or hypersplenism

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4
Q

What could trigger Idiopathic Thrombocytopenic Purpura?

A
EBV
HIV
Lymphoma
Collagenosis
Quinine use
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5
Q

How do you diagnose ITP?

A

Patient presents with clinical history of thrombocytopenia i.e. bruising, petechia & mucosal bleeds

+ FBC showing thrombocytopenia

Very rarely need marrow tests

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6
Q

How do we treat ITP acutely?

A

Steroids & IV IgG

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7
Q

How do we manage ITP chronically?

A

Most cases are just one episode but if its long term:

  • Platelet count good between episodes? Then leave it
  • Platelet count consistently low? –> Thombopoietin Analogues
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8
Q

How does liver disease contribute to bleeding?

A

Liver produces a lot of coagulation factors + Fibrinogen + Thrombopoietin
So someone with chronic liver disease will produce less –> Excess of both bleeding

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9
Q

Where do people with liver disease tend to bleed from?

A

Varices

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10
Q

Drugs cause most cases of acquired bleeding disorder, what ones particularly?

A
Warfarin
Heparins
Aspirin
Anti-platelets
DOACs
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11
Q

What is haemorrhagic disease of a newborn?

A

Babies with immature coagulation system + Vit K deficiency —> Fatal Haemorrhage

Very rare in the western world as we give newborns a Vit K inj

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