ACOG Summaries Flashcards
Parvovirus B19 in Pregnancy
- Increased activity in the USA 2. Maternal to fetal transmission in 17-33% of infected pregnancies 3. 5-10% risk of adverse fetal outcomes (fetal anemia, nonimmune hydrops, fetal loss)
Signs of Parvovirus Infection
Fever, myalgia, malaise, reticular rash, arthralgia (Infectious period occurs before symptoms start)
At what gestational ages is there an increased risk of adverse fetal outcomes with Parvovirus infection?
9-20 weeks
When should pregnant individuals be screened for syphilis?
1st prenatal visit, 3rd trimester, and at birth
How long does it take for POPs to become effective?
48 hours
Time window of taking POPs
Within 3 hours of the prior 24h dose
Fetal risks of measles infection
EPL, still birth, LBW, PTD
How long do you stay isolated in case of measles
4 days after rash appears
Post-exposure prophylaxis for measles
Pregnant: IVIG 400 mg/kg within 6 days
Non-pregnant: MMR vaccine OR IVIG within 72h
When should RSV vaccine be given
Between 32w0d-36w6d through months of Sep through Jan
New FDA approved postpartum depression treatment
Zuranolone: GABA A receptive positive modulator. Oral agent. Can be used if onset within 3rd trimester or within 4 weeks PP.
Brexanolone: IV treatment. 60hour in-hospital ifusion
Zuranolone dosing
50mg tablet in the evening with a fatty meal for 2 weeks
Can be reduced to 40mg if CNS depressant effects occur
30mg if severe hepatic or renal impairment .
Can cause fetal harm
Vaccines contraindicated in pregnancy
MMR, varicella, HPV (ok in postpartum and with nursing)
Acceptable vaccines in pregnancy
Inactivated Flu, Pneumococcal, meningococcal, Tdap, HepA, HepB, COVID19
When can Tdap be given
Between 27 and 36 weeks
Risk factors associated with SCD and pulmonary arterial hypertension
Hx PE, Chest pain, Syncope, Hypoxia
