Acne Flashcards
T/F Approximately 85% young people between 12-24 years have acne
T and preadolescent acne is affecting children 7-11 years
35% women and 20% men still report having acne in their 30s whilst 26% women and 12% men still report acne in their 40s
T
T/F Caucasian girls and females have a tendency to more severe nodulocystic disease than other groups
F Caucasian boys and males have a tendency to more severe nodulocystic disease than other groups
What theoretical foods are associated with acne?
Theories include: milk (skimmed milk), whey protein used in body building supplements, high glycemic-load, B12 supplementation
What three things are involved in the pathogenisis of acne?
- Follicular hyperkeratinization 2. hormonal influences 3. inflammation, in part mediated by P.acnes
T/F Dehydroepiandrosterone (DHEA) is a weak androgen converted to the more potent testosterone by 3-HSD and 17b-HSD
T
T/F the rise in serum levels of DHEAS in pre-pubescant children –> acne
T
T/F the theory is systemically administed Estrogen increases sebum production
F decreases
T/F CD8 T cells and levels of IL-2 have been shown to be increased perifollicularly prior to hyperkeritinization
F CD4 T cells and levels of IL-1
T/F P.acnes is a Gram-positive, aerobic cocci found deep within the sebaceous follicle
F it’s a rod, often found with smaller numbers of P.granulosum
T/F P.acnes produces porphyrins (primarily coproporphrin III) that fluroesces with Wood’s lamp illumination
T
T/F Acne fulimans- patients typically have severe acne prior to the onset
F tends t be mild-moderate
T/F Erythema nodosum may also arise in association with acne fulminans
T
What does SAPHO stand for?
Synovitis Acne Pustulosis Hyperostosis Ostitis (can also accompany acne fulminans. Other associations include late-onset congenital adrenal hyperplasia and anabolic steroid use, including tesosterone)
T/F you should stop Isotretinoin immediately in someone with acne fulminans
True…for about 2 weeks whilst given Prednislone but then you restart at low dose eg 0.1mg/kg/day
What is the follicular occlusion triad?
Acne conglobata, Hydrenadenitis supprativa, Pilonoidal sinuses, and disecting cellulitis of the scalp
What is PAPA syndrome?
Pyogenic Arthritis, Pyoderma gangrenosum, and Acne conglobata
AD autoinflammatory disorder
PAPASH- add HS
T/F PAPA is caused by mutation in PSTPIP1 which encodes Proline-Serine-Threonine Posphatase Interacting Protein 1 (PSTPIP1)
T
What is Morbihan disease?
An unusual and disfiguring complication- solid facial edema. Clinically there is a distoriton of the midline face and cheeks due to soft tissue swelling. The wooding induration may be accompanied by erythema
30% newborns are born with neonatal cephalic pustulosis
F 20% newborns, lesions usually appear about 2 weeks of age and generally resolve within the first 3 months of life
T/F Neonatal cephalic pustulosis responds to topical imidazoles
T eg 2% Ketoconazole cream
T/F Comedo formation is prominent in infantile acne
T- scarring may develop in up to half of patients
T/F pathogenisis of infantile acne includes elevated levels of LH in males and elevated DHEA in both boys and girls
T LH stimulates testicular production, DHEA produced by infantile adrenal gland
T/F oral antibiotics are first line treatment of infantile acne
F topical retinoids (eg tretinoin, adapalene) and benzyol peroxide are first line
