Acids, Bases, And Buffers Flashcards

1
Q

Reactants combine to give __________.

A

Products

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2
Q

Products can fall apart to give ____________.

A

Reactants

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3
Q

___________ ____________ is the process of reactants combining to yield products and products breaking apart to yield reactants.

A

Dynamic equilibrium

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4
Q

When a system is a state of dynamic equilibrium is disturbed it will react to reestablish the equilibrium condition, this is called ______________________.

A

Le Chatelier’s principle

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5
Q

When is a system in a state of equilibrium?

A

When there is a balance between reactants and products.

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6
Q

What is balance defined by?

A

Thermodynamics

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7
Q

As the equilibrium constant (K) increases, the reaction favors _________, as K decreases, the reaction favors ________ ________.

A

Products, starting materials.

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8
Q

If you add products, the equilibrium will shift towards __________.

A

Reactants

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9
Q

If you remove products, the equilibrium will shift toward ________.

A

Products

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10
Q

An acid is a proton ________.

A

Donor

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11
Q

A base is a proton _________.

A

Acceptor

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12
Q

When an acid donates a proton, it is converted into its __________ _____.

A

Conjugate base.

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13
Q

When a base accepts a proton, it is converted into its __________ _____.

A

Conjugate acid

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14
Q

An ______________ _______ can behave as either an acid or a base.

A

Amphoteric species

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15
Q

H20 is an _______ ____.

A

Amphoteric species

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16
Q

The stronger the acid, the _______ the conjugate base.

The weaker the acid, the _______ the conjugate base.

A

Weaker

Stronger

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17
Q

A stronger acid is more determined to…

A stronger base is more determined to…

A
  • give its proton to some base

- take a proton from some acid

18
Q

Strong bases are _______ _____ _________.

A

Soluble ionic hydroxides

19
Q

When a strong base dissolves in water…

A

It essentially all dissociates to ions.

20
Q

Weak acids do or do not ionize 100% in water?

A

Do not (they establish equilibrium)

21
Q

Weak bases establish equilibrium by ….

A

Accepting a proton from water.

22
Q

The buffer in a solution …

A

Resists changes in pH

23
Q

Buffers contain a _____ ______ and a _______ _____.

A

Weak acid, conjugate base

24
Q

What equation is used to determine the ration of weak acid to its conjugate base at a given pH?

A

Henderson-Hasselbach

25
Q

When the concentration of a weak acid and its conjugate base are equal, the pH is equal to ….

A

The pKa (Ka weak acids)

26
Q

Nonionized drugs are _______ ________ and easily…

A

Lipid soluble, penetrate the blood/placental barriers.

27
Q

The ionized form of a drug is…

A

Water soluble (hydrophilic)

28
Q

The degree of ionization or nonionization determines …

A

Drug effectiveness.

29
Q

What are the 3 steps of determination?

A
  • 1 Is drug a weak acid or weak base?
  • 2 What is pKa of drug? (reference)
  • 3 pH target of solution (body)
30
Q

Weak acids become _____ nonionized as pH falls.

A

More (H+ increases)

Acid + Acid = nonionized

31
Q

Weak acids unite with _______ charged ions.

A

Positively (Na+, Mg++, Ca++)

32
Q

What are salt drugs?

A

Na+, Mg++, Ca++

33
Q

Recognize a salt drug as the base form of a…

A

Weak acid. (Sodium pentobarbital)

34
Q

Weak bases become _____ unionized as pH >.

A

More (H+ decreases)

Base + Base = nonionized

35
Q

Weak bases unite with _____ charged ions.

A

Negatively (Cl- SO4^2-)

36
Q

If you recognize “drug” chloride, “drug” sulfate, they are the salt form of a

A

Weak base (lidocaine hydrochloride, morphine sulfate)

37
Q

The ___________ drug penetrates the BBB and placental barrier.

A

Nonionized

38
Q

The ___ the nonionized portion of the drug, the ___ the transfer to brain and fetus.

A

> ,>

39
Q

3 Weak Acid Drugs:

A
  • Thiopental
  • Barbiturates
  • Propofol??
40
Q

4 Weak Base Drugs:

A
  • Lidocaine (locals)
  • Morphine (opioids)
  • Versed (benzos)
  • Propofol??
41
Q

The pH of the fetus is _____ than maternal pH

A

Lower

42
Q

The circulating nonionized drug does or does not cross the placental barrier?

A

Does