Acid/Base Practice (Kwon Exam 2) Flashcards
Identify the functional group of A, B, C, and D.
Consider all of the acidic and basic functional groups found within the structure of ciprofloxacin and match each pKa to the correct group. Identify each functional group as either acidic or basic.
Evaluate each physiological environment to determine if the functional group is predominantly (>50%) ionized, unionized, or will be 50% ionized/50% unionized
Directly modify each acidic functional group to show the ionized form. The ionized form of each of these functional groups represents the conjugate base form of the functional group.
Identify the B-dicarbonyl functional group (enol form) in the following drug molecules:
Identify the sulfonamides in the two molecules pictured:
Identify urea in the following molecule:
Is the molecule pictured an acid?
NO!
What are two differences between tetrazoles and carboxylic acids?
- tetrazoles has a slightly higher pKa (less acidic)
- tetrazoles are more lipophilic
Identify the tetrazole in the angiotensin II receptor blocker:
Identify the thiols (sulfydryls) in the following molecules:
Which main amino acid has a thiol group as its side chain?
cysteine
What functional group is being shown in the box here?
phosphate
What functional group is being shown in the box here?
phosphonate
Identify the functional group in the molecule:
aromatic amine
What functional group is being shown here?
imine
What functional group is being shown in the box?
imine
What functional group is being shown in the box?
hydrazine
What functional group is being shown here?
amidine
What functional group is being shown here?
guanidine
