Acid Base Physiology Flashcards

1
Q

A low PO2 in the blood directly stimulates medullary chemoreceptors

A

False

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

CO2 in the blood directly stimulates medullary chemorecptors

A

False

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

H+ ions in the blood directly stimulate medullary chemoreceptors

A

False

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

H+ ions in the blood directly stimulate carotid body chemoreceptors

A

False

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

The baroreceptor response to hypotension includes respiratory stimulation

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

A pH of 7.0 equates to a hydrogen ion concentration of 100nmol/L

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

pH is defined as the neagtive Log of the hydrogen ion concentration in mol/L

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Albumin is an important intracellular buffer

A

False

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Carbonic anhydrase catalyses the reaction between water and CO2

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Alkalosis lowers free inonized calcium concentration

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

The following represent typical O2 content values that would be expceted from each of these sites
Renal vein - 125 mL/L

A

False

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

The following represent typical O2 content values that would be expceted from each of these sites
Coronary sinus - 90mL/L

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

The following represent typical O2 content values that would be expceted from each of these sites
Radial Artery - 200mL/L

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

The following represent typical O2 content values that would be expceted from each of these sites
Umbilical Vein 130mL/L

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

The following represent typical O2 content values that would be expceted from each of these sites
Pulmonary vein 150mL/L

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

The following values would be compatible with a healthy person having lived at 5,000 m for 7 days
[HCO-] 31 mmol/L

A

False

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

The following values would be compatible with a healthy person having lived at 5,000 m for 7 days
PaO2 of 10.6 kPa

A

False

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

The following values would be compatible with a healthy person having lived at 5,000 m for 7 days
PaCO2 of 3.9 kPa

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

The following values would be compatible with a healthy person having lived at 5,000 m for 7 days
resting HR of 95/min

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

The following values would be compatible with a healthy person having lived at 5,000 m for 7 days
right shift of Hb/O2 dissociation curve

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

The pKa of H2CO3 is 6.1 at 37 C

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

The majority of filtered HCO3- is reabsorbed in the loop of henle

A

False

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Phosphate is an important extracellular buffer

A

False

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

The distal convoluted tubule determines the final urine pH

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
H+ ions are echanged for K+ ions in the kidney
True
26
With regards to oxygen binding | Affinity for haemoglobin is higher than for methaemoglobin
True
27
With regards to oxygen binding | Affinity for fetal haemoglobin is higher than for haemoglobin
True
28
With regards to oxygen binding | Affinity for myoglobin is higher than for haemoglobin
True
29
With regards to oxygen binding | Each molecule of myoglobin can bind up to 4 molecules of oxygen
False
30
With regards to oxygen binding | The normal P50 for Hb is approximately 5.3 kPa
False
31
The following are buffers in renal tubular fluid | Albumin
False
32
The following are buffers in renal tubular fluid | Ammonia
True
33
The following are buffers in renal tubular fluid | Bicarb
True
34
The following are buffers in renal tubular fluid | Phosphate
True
35
The following are buffers in renal tubular fluid | Urea
False
36
Carbon dioxide is 5 times more soluble in plasma than O2
false
37
Carbon dioxide content in venous blood is approximately 500ml/L
true
38
Carbon dioxide is largely carried in blood as bicarbonate
True
39
Carbon dioxide conversion to carbamino compounds requires carbonic anhydrase
false
40
Carbon dioxide content in blood increases as Hb unloads O2
True
41
The following would be expected at the peak of vigorous exercise O2 consumtion increased 10 fold
True
42
The following would be expected at the peak of vigorous exercise Overall O2 extraction ratio increased to 0.75
False
43
The following would be expected at the peak of vigorous exercise coronary O2 extraction ratio doubled
false
44
The following would be expected at the peak of vigorous exercise cardiac output increased 10 fold
false
45
The following would be expected at the peak of vigorous exercise minute ventilation increased 10 fold
True
46
Acutely reducing the inspired O2 concentration to 10% at sea level will cause increased urinary pH
True
47
Acutely reducing the inspired O2 concentration to 10% at sea level will cause increased cardiac output
True
48
Acutely reducing the inspired O2 concentration to 10% at sea level will cause increased capacity of Hb for oxygen
true
49
Acutely reducing the inspired O2 concentration to 10% at sea level will cause increased erythropoietin secretion
true
50
Haemoglobin contains 2 alpha chains
True
51
Haemoglobin carries 4 molecules of O2 per chain
False
52
Haemoglobin is a 4 chain structure
True
53
Haemoglobin contains ferrous iron
True
54
Haemoglobin is a polypeptide
True
55
The O2 content of blood is decreased in COHb
True
56
The O2 content of blood is decreased in methaemoglobinaemia
True
57
The O2 content of blood is decreased in Anaemia
True
58
The O2 content of blood is decreased in chronic renal failure
True
59
The O2 content of blood is decreased in hyperbaric conditions
False
60
The O2-Hb dissociation curve moves to the right with an increase in temperature
True
61
The O2-Hb dissociation curve moves to the right when 2,3-DPG levels increase
True
62
The O2-Hb dissociation curve moves to the right when CO2 concentration increases
True
63
The O2-Hb dissociation curve moves to the right with an increase in hydrogen ion concentration
true
64
The O2-Hb dissociation curve moves to the right on exercise
True
65
The O2-Hb dissociation curve moves to the left in pregnancy
False
66
The O2-Hb dissociation curve moves to the left in stored blood
True
67
The O2-Hb dissociation curve moves to the left in Fetal Hb
True
68
The O2-Hb dissociation curve moves to the left in Cyanide poisening
False
69
The O2-Hb dissociation curve moves to the left in CO poisening
True
70
The following drugs are bases | Atracurium
True
71
The following drugs are bases | bupivicaine
True
72
The following drugs are bases | diclofenac
False
73
The following drugs are bases | Morphine
True
74
The following drugs are bases | Thiopental
False
75
The following are normal for an adult at rest | Anion Gap of 12 mmol/l
True
76
The following are normal for an adult at rest | CO2 production of 500ml/min
False
77
The following are normal for an adult at rest | hydrogen ion concentration of 40 mmol/L
False
78
The following are normal for an adult at rest | Carboxy-Hb of 0.5%
True
79
The following are normal for an adult at rest | Fetal-Hb of 0.5%
True
80
The following would be compatible with a 10 day history of pyloric stenosis Raised aldosterone level
True
81
The following would be compatible with a 10 day history of pyloric stenosis Serum Chloride of 86 mmol/l
True
82
The following would be compatible with a 10 day history of pyloric stenosis serum potassium of 5.5 mmol/L
False
83
The following would be compatible with a 10 day history of pyloric stenosis Arterial PCO2 of 5.9 kPa
True
84
The following would be compatible with a 10 day history of pyloric stenosis Aterial pH of 7.54
True
85
The following are true about renal acid-base regulation | Aldosterone is the main regulator of urinary pH
False
86
The following are true about renal acid-base regulation filtered bicarb acts as a buffer in tubular fluid
True
87
The following are true about renal acid-base regulation | Hydrogen ions are secreted by the incalated cells in the PT
False
88
The following are true about renal acid-base regulation | hydrogen ion secretion in the PCT is dependant on carbonic anhydrase
True
89
The following are true about renal acid-base regulation | the kidney excretes the bodys largest acid load
False
90
The haldane effect enhances carbon dioxide unloading in the lungs
True
91
The haldane effect is due mainly to enhanced formation/breakdown of carbamino compounds
True
92
The haldane effect is more effective in a patient breathing 100% O2
False
93
The haldane effect is related to the Hb-O2 interaction
True
94
The haldane effect results directly in part from changes in 2,3 DPG
False