Acid-Base / Electrolytes / Fluids Flashcards

1
Q

What are the four primary acid-base disorrders?

A

Metabolic Acidosis
Metabolic Alkalosis
Respiratory Acidosis
Respiratory Alkalosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Respiratory acid-base disorders bring primary changes in ___ and secondary (compensatory) changes in _____.

A

CO2

HCO3-

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Metabolic acid-base disorders bring primary changes in ___ and secondary (compensatory) changes in _____.

A

HCO3-

CO2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What primary acid-base disorder is indicated by the ABG below….

7.21/30/100/15

A. Metabolic Acidosis
B. Metabolic Alkalosis
C. Respiratory Acidosis
D. Respiratory Alkalosis

A

A. Metabolic Acidosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the compensatory response in a metabolic acidosis?

A

Decrease CO2 concentration through hyperventilation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What processes can result in a Metabolic acidosis?

A
Lactic Acidosis
DKA
Ingestion (Methanol, Ethylene Glycol, ASA)
Renal Failure
Diarrhea (HCO3- Loss)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What primary acid-base disorder is indicated by the ABG below….

7.50/50/100/30

A. Metabolic Acidosis
B. Metabolic Alkalosis
C. Respiratory Acidosis
D. Respiratory Alkalosis

A

B. Metabolic Alkalosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the compensatory response in metabolic alkalosis?

A

Increased CO2 concentration through hypoventilation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What processes can lead to metabolic alkalosis?

A
  1. TPN Administration
  2. Vomiting (H+ loss)
  3. Loop diuretics
  4. HCO3- Administration
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What primary acid-base disorder is indicated by the ABG below….

7.14/56/100/27

A. Metabolic Acidosis
B. Metabolic Alkalosis
C. Respiratory Acidosis
D. Respiratory Alkalosis

A

C. Respiratory Acidosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the compensatory response in a respiratory acidosis?

A

Increased HCO3- buffering in the kidneys

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What processes can lead to a respiratory acidosis?

A
Alveolar hypoventilation
V/Q mismatch
Alterations in CNS respiratory drive
Respiratory muscle fatigue
Pulmonary disease
Mechanical ventilation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

If an intubated and mechanically ventilated patient developed a respiratory acidosis, would this be the result of hypoventilation or hyperventilation?

How could this be corrected?

A

Hypoventilation (The patient is not breathing fast enough)

This can be corrected through increasing the ventilation rate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What primary acid-base disorder is indicated by the ABG below….

7.56/25/100/18

A. Metabolic Acidosis
B. Metabolic Alkalosis
C. Respiratory Acidosis
D. Respiratory Alkalosis

A

D. Respiratory Alkalosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the compensatory response to a respiratory alkalosis?

A

Decreased HCO3- production in the kidneys

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Is respiratory alkalosis commonly due to hypoventilation or hyperventilation?

A

Hyperventilation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What processes can cause respiratory alkalosis?

A
  1. Pain
  2. CVA
  3. Anxiety
  4. Trauma (Flail Chest)
  5. Hypoxemia, Altitude
  6. Pulmonary Edema
  7. Heart Failure
  8. Sepsis
  9. Mechanical Ventilation
  10. Over-correcting Metabolic acidosis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What are causes of a WAGMA (Wide anion gap metabolic acidosis)?

A

MUDPILES

Methanol
Uremia (renal failure)
Diabetic ketoacidosis
Propylene glycol
Infection, inborn errors of metabolism
Lactic acidosis
Ethylene glycol
Salicylate
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

A 65 y.o. male s/p CABG is intubated and placed on ventilation in the ICU. Following intubation, an ABG is drawn which shows…..

7.27/55/250/25(-2)/100%

What is the primary acid/base disorder?

Is this likely a result of?

How could this be corrected?

A

Respiratory Acidosis

This is likely a result of hypoventilation (holding onto too much CO2)

Increase the ventilation rate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

A 40 y.o female involved in a single vehicle MVA arrives in the ED. On exam she is found to have a fail chest. As respiratory failure seems imminent, she is intubated. Following intubation, an ABG is drawn which shows….

7.54/24/370/22/100%

What is the primary acid/base disorder?

Is this likely a result of?

How could this be corrected?

A

Respiratory Alkalosis

This is likely due to mechanical hyperventilation. (Losing too much CO2)

Decrease the ventilation rate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

A 6 y.o. male is brought into the ED complaining of emesis, abdominal pain, and polyuria. A UA is ordered which shows a large amount of glucose and the presence of ketones. This is concerning and prompts an ABG draw, which shows…..

7.25/16/131/7/99%

What is the primary acid/base disorder?

What is the likely underlying condition this patient has?

How are they trying to compensate?

A

Metabolic Acidosis

This patient likely has undiagnosed DM and is now presenting in DKA

He was trying to compensate by hyperventilating and ‘blowing down’ his CO2 levels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

_______ are IV fluids that contain water, dextrose, Na+, Cl-, and other electrolytes

A

Crystalloids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

______ _____ contain mostly Na+ and Cl- but also have lactate, K+, and Ca2+

A

Lactated Ringer’s (LR)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

______ contain packed red blood cells, pooled human plasma (5% albumin, 25% albumin), semisynthetic glucose polymers (dextran), and semisynthetic hydroxyethyl starch (hetastarch)

A

Colloids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Are colloids more likely to remain in the intravascular space or the interstitial space?

A

Intravascular

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Why should colloids be avoided in patient who are requiring fluid resuscitation (ie: dehydration)?

A

Colloids will draw water out of the interstitial space

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

When would symptoms of intravascular fluid depletion likely manifest?

A

Once 15% (750 mL) of blood volume is lost

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

What is the recommended ‘fluid’ of choice in fluid resuscitation?

A

Crystalloids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

What are the signs and symptoms of intravascular fluid depletion?

A
  1. Tachycardisa
  2. Hypotension
  3. Orthostatic
  4. AKI (Increased BUN/sCr)
  5. Dry Mucus Membranes
  6. Decreased Skin Turgor
  7. Reduced Urine Output
  8. Dizziness
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

____ water is also referred as D5W and is metabolized to water and CO2 in the body

A

Free Water (D5W)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

What THREE things are considered when adjusting maintenance fluids?

A
  1. Input
  2. Output
  3. Insensible Loss
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

Which ‘fluid’ is commonly used for maintenance fluids?

A. Crystalloids
B. Colloids
C. Free Water (D5W)

A

C. Free Water (D5W)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

Increased osmolarity would likely result in fluid shift ______ (out of/into the cell, cell _______ (hydration/dehydration and _______ (shrinkage/growth)

A

Out of

Dehydration

Shrinkage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

Decreased osmolarity would likely result in fluid shift ______ (out of/into the cell, cell _______ (hydration/dehydration) and _______

A

Into

Hydration

Hemolysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

In what THREE ways can fluid be classified in terms of osmolarity?

A
  1. Hypertonic (Water out of the cells)
  2. Isotonic
  3. Hypotonic (Water into the cell)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

What are TWO common uses for hypertonic saline?

A
  1. TBI with increased ICP and MAP

2. Symptomatic Hyponatremia (AMS, Coma)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

When should hypertonic saline be AVOIDED?

A
  1. Chronic Asymptomatic Hyponatremia
  2. Hyponatremia with Hyperglycemia (ex: DKA)
  3. Hyponatremia with Hypovalemia (ex: CHF)
38
Q

What is the maximal safe amount of change in serum Na+ levels over 24 hours?

A

10-12 mmol/L

39
Q

What are common complications of hypertonic saline?

A
  1. Hypokalemia
  2. Hyperchloremic Acidosis
  3. Hypernatremia
  4. Phlebitis
  5. Heart Failure (Fluid Overload)
  6. Osmotic Demyelination Syndrome (Rapid Correction of Hyponatremia)
  7. Hypotension (Rapid Administration)
40
Q

What are complications of IV hypotonic fluids?

A
  1. Hemolysis of cells

2. Death

41
Q

IVF with an osmolarity less than ____ mOsm/L should be AVOIDED

A

150 mOsm/L

42
Q

________ hyponatremia is caused by excess Na+ and fluid, but the fluid excess predominates

A

Hypervolemic Hyponatremia

43
Q

________ hyponatermia normal total body Na+ but excess fluid, appears diluted

A

Normovolemic Hyponatremia

44
Q

_________ hyponatremia is a deficit of both fluid and Na+ but total Na+ is decreased more than total body water

A

Hypovolemic Hyponatremia

45
Q

What is an example of a disease or process(es) that can cause hypervolemic hyponatremia?

Normovolemic?

Hypovolemic?

A

Hypervolemic:

CHF
Cirrhosis

Normovolemic:

SIADH

Hypovolemic:

Emesis, Diarrhea, Fever
Third-Spacing
Diuretics

46
Q

How is hypervolemic hyponatremia treated?

A
  1. Na+ / Water restriction
  2. Treat underlying cause
  3. Vasopressin receptor antagonist
47
Q

How is normovolemic hypoonatremia treated?

A
  1. Remove offending agent (If applicable)
  2. Restrict fluids
  3. Demeclocyline (Tx SIADH)
  4. Vasopressin receptor antagonist
48
Q

How is hypovolemic hyponatremia treated?

A
  1. Fluid Resuscitation
49
Q

What are common causes of hyponatremia

A
  1. Increased ADH
  2. Volume Depletion / Hypoperfusion
  3. SIADH / Cortisol Deficiency
  4. Medication (Diuretics, SSRIs)
  5. Renal Failure
50
Q

What are clinical manifestations of mild hyponatremia (120-125)?

Moderate (115-120)?

Severe (<115)?

A

Mild:

Nausea, Malaise

Moderate:

HA, Lethargy, Obtundation, Confusion

Severe:

Delirium, Sz, Coma, Death

51
Q

What are common symptom manifestation of hypernatremia (>145)

A
  1. Lethargy, Weakness
  2. Twitching, Sz
  3. Coma
  4. Death (Late/Severe)
52
Q

What are common causes of hypernatremia?

A
  1. Loss of Water (Fever, Burns, Infection)
  2. Diabetes Insipidus)
  3. Sodium Retention
53
Q

What complications may occur if hypernatremia is corrected too rapidly?

A

Cerebral Edema
Seizures
Neurologic Damage
Death

54
Q

K+ is the primary ________ (intracellular/extracellular) cation while Na+ is the primary ________ (intracellular/extracellular) cation

A

Intracellular

Extracellular

55
Q

What are common causes of hypokalemia?

A
  1. Increased pH
  2. Insulin Load
  3. Hypothermia
  4. Increased GI Losses (vomiting, diarrhea, laxatives)
  5. Diuretics
  6. Hypomagnesemia
56
Q

What are symptoms and manifestations of hypokalemia?

A
  1. Muscle Weakness
  2. Flattened T waves
  3. Arrhythmias (Bradycardia, V Tach, V fib)
  4. Rhabdomyolysis
57
Q

How should a hypokalemic patient WITHOUT EKG chagnes be treated/managed?

A

PO K+ Supplementation

58
Q

At what K+ should hypokalemia be treated with IV replacement?

What else should be monitored?

A

< 2.5

These patients should likely have continuous EKG monitoring

59
Q

What are common causes of hyperkalemia?

A
  1. Increase K+ intake
  2. Acidosis
  3. Insulin Deficiency
  4. Kidney Dysfunction
60
Q

What are symptoms and manifestations of hyperkalemia?

A
  1. Muscle Weakness / Paralysis
  2. Peaked T-waves
  3. V Fib is Possible
  4. Additional Electrolyte abnormalities
61
Q

When would urgent and immediate treatment of hyperkalemia be indicated?

A
  1. K+ >6.5
  2. Severe muscle weakness
  3. EKC Change
62
Q

What is used to prevent hyperkalemia induced arrhythmias?

A

IV Calcium

63
Q

T/F: IV Ca2+ will decrease serum K+ levels

A

False

It only antagonizes the effect of K+ on cardiac conduction

64
Q

IV Ca2+ should be avoided in patients taking what anti-arrhythmic

A

Digoxin

65
Q

Other than IV Ca2++, what additional ‘primary’ treatment options are available to treat hyperkalemia?

What are the ‘secondary’ or additional treatment options are used to treat hyperkalemia?

A

Primary:

  1. Insulin / Glucose
  2. Sodium Bicarbonate (Avoid in renal disease)
  3. Beta-2 Adrenergic Agonists (Avoid in coronary ischemia)

Secondary:

  1. Diuretics
  2. Cation-resin Exchange
  3. Dialysis
  4. Kayexalate
66
Q

What are common causes of hypomagnesemia (< 1.7)?

A
  1. Impaired Absorption (UC, Diarrhea)
  2. Alcoholism
  3. Hypokalemia
  4. Diuretics
67
Q

What are signs and symptoms of hypomagnesemia?

A

Tetany, Twitching
Arrhythmia
HTN
Sudden Death

68
Q

What is a common cause of hypermagnesemia (>2.3)?

A

Renal Insufficiency

69
Q

What are signs and symptoms of hypermagnesemia?

A
  1. Nausea, Emesis
  2. Bradycardia, Heart Block, Asystole
  3. Respiratory Failure
  4. Death
70
Q

How is hypermagnesemia treated?

A
  1. Discontinue Mg2+ containing medications
  2. IVF and Diuretics is Asymptomatic
  3. IV Ca2++ if cardiac symptoms
  4. HD in the setting of kidney disease
71
Q

What are common causes of hypophosphatemia (<2.5)?

A
  1. Increased Renal Elimination (Diuretics)
  2. Re-feeding Syndrome
  3. Respiratory Alkalosis
  4. DKA Treatment
72
Q

What are common signs and symptoms of hypophosphatemia?

A
  1. Tissue Hypoxia
  2. Neurologic (Confusion, Sz, Coma)
  3. Cardiopulmonary (Respiratory Failure, CHF)
73
Q

What are common causes of hypomagnesemia (< 1.7)?

A
  1. Impaired Absorption (UC, Diarrhea)
  2. Alcoholism
  3. Hypokalemia
  4. Diuretics
74
Q

What are signs and symptoms of hypomagnesemia?

A

Tetany, Twitching
Arrhythmia
HTN
Sudden Death

75
Q

What is a common cause of hypermagnesemia (>2.3)?

A

Renal Insufficiency

76
Q

What are signs and symptoms of hypermagnesemia?

A
  1. Nausea, Emesis
  2. Bradycardia, Heart Block, Asystole
  3. Respiratory Failure
  4. Death
77
Q

How is hypermagnesemia treated?

A
  1. Discontinue Mg2+ containing medications
  2. IVF and Diuretics is Asymptomatic
  3. IV Ca2++ if cardiac symptoms
  4. HD in the setting of kidney disease
78
Q

What are common causes of hypophosphatemia (<2.5)?

A
  1. Increased Renal Elimination (Diuretics)
  2. Re-feeding Syndrome
  3. Respiratory Alkalosis
  4. DKA Treatment
79
Q

What are common signs and symptoms of hypophosphatemia?

A
  1. Tissue Hypoxia
  2. Neurologic (Confusion, Sz, Coma)
  3. Cardiopulmonary (Respiratory Failure, CHF)
80
Q

What TWO diseases are commonly seen with hyperphosphatemia?

A
  1. CKD

2. Hypoparathyroidsm

81
Q

T/F: Patient with hyperphosphatemia are typically asymptomatic

A

True

82
Q

How is Hyperphosphatemia treated?

A
  1. Dietary restrictions
  2. Saline Infusion
  3. Dialysis
  4. Phosphate Binders (Calcium Carbonate, Calcium Acetate)
83
Q

What are common causes of hypocalcemia?

A
  1. CKD
  2. Hypoparathyroidism
  3. Vitamin D Deficiency
  4. Alcoholism
84
Q

What are some of the many treatment options for hypercalcemia?

A
  1. Isotonic Saline Hydration
  2. Calcitonin
  3. Bisphosphonates
  4. Loop Diuretics
  5. Glucocorticoids
  6. Dialysis
85
Q

What are the acute hypocalcemia Sx?

A

Acute:

Syncope
CHF
Angina

86
Q

What are the neuromuscular hypocalcemia Sx?

A
Numbness
Tingling
Cramping
Tetany 
Wheezing
Hoarseness
87
Q

What are the neurologic hypocalcemia Sx?

A

Irritability
Fatigue
Sz

88
Q

What are the chronic dermatological hypocalcemia Sx?

A
Coarse Hair
Brittle Nails
Psoriasis
Dry Skin
Poor Dentition
89
Q

What are the TWO most common causes of hypercalcemia?

A
  1. Malignancy

2. Hyperparathyroidism

90
Q

What are the CNS Sx of hypercalcemia?

GI Sx?

Renal?

Cardiac?

A

CHS:

Lethargy, Weakness, Confusion

GI:

Constipation, Nausea

Renal:

Polyuria, Nocturia, Stones

Cardiac:
Syncope, Arrhythmia

91
Q

What are some of the many treatment options for hypercalcemia?

A
  1. Isotonic Saline Hydration
  2. Calcitonin
  3. Bisphosphonates
  4. Loop Diuretics
  5. Glucocorticoids