acid base Flashcards

1
Q

what is normal arterial pH

A

7.35-7.45

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2
Q

what is normal CO2

A

35-45

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3
Q

what is normal HCO3

A

22-26

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4
Q

where is the collection of an ABG done?

A

radial artery
may use femoral, brachial, or dorsalis pedis in emergencies

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5
Q

what would a nurse do if they cannot find the radial artery

A

use a Doppler
a respiratory therapy is usually the most experienced
watch over the medical resident

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6
Q

when would the radial artery be hard to find?

A

edematous, elderly, dehydrated

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7
Q

can a critical care nurse take an ABG?

A

yes, a critical care nurse can take the blood from the Alaris pump central line insert

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8
Q

what information is obtained from an ABG?

A

acid base status
oxygenation (dissolved O2, saturation of hemoglobin)

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9
Q

What are the indications for an ABG?

A

Assess the ventilatory status
Oxygenation and acid base status
To reassess the response to an intervention

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10
Q

what are the contraindication for an ABG

A

bleeding disorder
AV fistula
severe peripheral vascular disease, absence of an arterial pulse
infection over site

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11
Q

what are the differences between and ABG and pulse oximetry

A

Pulse oximetry uses light absorption at two wavelengths to determine hemoglobin saturation
Pulse oximetry is non-invasive and provides immediate and continuous data
Pulse oximetry does not assess ventilation (pCO2) or acid base status
Pulse oximetry becomes unreliable when saturations fall below 70-80%
Technical sources of error (ambient or fluorescent light, hypoperfusion, nail polish, skin pigmentation)
Pulse oximetry cannot interpret methemoglobin or carboxyhemoglobin

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12
Q

what does heparin do for an ABG

A

Eliminates dilution problem
Mixing becomes more important
May alter sodium or potassium levels

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13
Q

how would an ABG be performed

A

Withdraw the needle and hold pressure on the site
Protect needle
Remove any air bubbles
Make sure blood is in contact with heparin
Gently mix the specimen by rolling it between your palms
Place the specimen on ice and transport to lab immediately

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14
Q

what are the collection problems associated with an ABG

A

air bubbles
specimen handling and transport

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15
Q

collection problems air bubbles

A

Gas equilibration between ambient air (pO2 ~ 150, pCO2 ~ 0) and arterial blood
pO2 will begin to rise, pCO2 will fall
Effect is a function of duration of exposure and surface area of air bubble

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16
Q

collection problems: specimen handling and transport

A
  • Minimize time from sample acquisition to analysis (within 30 minutes)
  • After specimen is collected and air bubble is removed, gently mix and invert syringe
  • Placing the ABG on ice may help minimize changes, depending on the type of syringe, pO2 and WBC count
    • Because the WBCs are metabolically active, they will consume oxygen
      -PaO2 will decrease, PaCO2 will increase
    • Plastic syringes are gas permeable
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17
Q

what is pH

A

an indicator of hydrogen ion H+ concentration

18
Q

what is normal venous pH

19
Q

what is the pH of water

A

7.0
neutral

20
Q

what is the pH range compatible with life

A

6.8-7.8
Outside of range can denaturize proteins

21
Q

how is pH regulated

A

Homeostatic mechanisms: Chemical buffer systems Lungs Kidneys
Net acid production: Net acid elimination

22
Q

what body systems regulate pH

A

lungs and kidneys

23
Q

which body system works faster to regulate pH

A

Lungs work a lot faster
Peak compensation for lungs is 1-24 hours
Peak compensation for kidneys is 12 hours-5 days

24
Q

what are the three major chemical buffer systems

A

Bicarbonate
Phosphate
Protein buffer systems

25
what are the intracellular buffers
proteins, organic and inorganic phosphates, hemoglobin in RBC
26
how do the lungs regulate pH
regulating by adjusting minute ventilation in response to the amount of CO2 in the blood CSF central chemoreceptor
27
what is the most powerful stimulant to respiration
A rise in the partial pressure CO2 (PaCO2) in arterial blood is a powerful stimulant to respiration, more powerful than the decrease of partial pressure of O2 (PaO2)
28
who would have a problem with desensitization to the rise of CO2
Older people and those with COPD are desensitized to rise in CO2, do not hyperoxygenate
29
how do the kidneys regulate pH
Regulating bicarbonate and H+ level by regenerating bicarbonate ions or reabsorb them from the renal tubular cells
30
what acid/ base imbalance is responded to the worst
metabolic alkalosis
31
what causes respiratory acidosis
hypoventilation
32
what are the clinical manifestations of respiratory acidosis
Increased ICP (acute) → increased CO2 → cerebrovascular vasodilation and increased cerebral blood flow - Papilledema and dilated conjunctival blood vessels - Hyperkalemia - Excessive H+ move into the cells - K+ has to come out of the cells
33
what causes respiratory alkalosis
Hyperventilation
34
what are the clinical manifestations of respiratory alkalosis
Lightheadedness - Decreased cerebral blood flow Inability to concentrate Numbness and tingling (affect nerve function) Dysrhythmias (hypokalemia)
35
what causes metabolic acidosis
due to loss of bicarb --> hyperchlomeric acid due to excessive accumulation of acid
36
what causes a loss of bicarb
diarrhea Lower intestinal fistulas Use of diuretics (carbonic anhydrase inhibitors: olamide: inhibit H+ secretion) Early renal insufficiency Excessive administration of chloride Administration of parenteral nutrition without bicarbonate or bicarbonate-producing solutes
37
what causes excessive accumulation of acid
Lactic acidosis (anaerobic metabolism) Exercise Infection Late phase of salicylate poisoning Kidney failure Methanol or ethylene glycol toxicity (found in automotive antifreeze and de-icing solutions, windshield wiper fluid, solvents, cleaners, fuels, and other industrial products) Ketoacidosis (diabetes) Starvation
38
what are the clinical manfestations of metabolic acidosis
Headache, confusion, drowsiness Increased respiratory rate and depth Nausea and vomiting Peripheral vasodilation and decreased cardiac output (when pH <7) Decreased blood pressure Cold and clammy skin Dysrhythmias Shock
39
what causes metabolic alkalosis
due to loss of h+ due to too much bicarb
40
what causes the loss of H+
Vomiting or gastric suction (most common) Hypokalemia (due to diuretic therapy: thiazides, lasix) Kidneys try to hold on potassium by excreting H+ K+ moves out of cell; H+ moves into cell
41
what causes too much bicarb
Ingestion of antacids containing bicarbonate The use of sodium bicarbonate during cardiopulmonary resuscitation
42
what are the clinical manifestations of metabolic alkalosis
Muscle twitching: affect neuromuscular function Hypokalemia: arrhythmia