Acid-Base Flashcards
Acid base normal ranges
normal physiological pH: 7.35-7.45
pH < 6.7 or < 7.7 is considered incompatible with life
Acidemia pH
pH < 7.35
Alkalemia pH
pH > 7.45
Carbonic acid/bicarbonate buffer system
H+ + HCO3- <–> H2CO3 <–> CO2 + H2O
left side occurs in “kidney” metabolic side; right side occurs in “lungs”
metabolic disorders involve changes in H+ or HCO3- levels, while repsiratory disorders involve changes in CO2
compensation for a particular disorder involves the opposite part (lungs compensate metabolic disorders, kidneys compensate respiratory disorders)
Henderson-Hasselbach equation
the relationship between pH and the concentration of acid-base pairs in buffer system
pH = pKa + log (base/acid)
pH = 6.1 + log (HCO3-/H2CO3)
pH = 6.1 + log (HCO3-/0.03 x pCO2) - pH of blood determined by ratio of HCO3- to pCO2
Normal blood gas values
PaCO2: 40 mmHg
HCO3: 24 mmHg
arterial blood is the best source for obtaining these readings
Adverse consequences: acidemia
cardiovascular, metabolic, CNS, others
Acidemia - cardiovascular AEs
decreased cardiac output, impairment of cardiac contractility, increase in pulmonary vascular resistance and arrhythmias
Acidemia - metabolic AEs
insulin resistance, inhibition of anaerobic glycolysis, hyperkalemia
Acidemia - CNS AEs
coma or altered mental status
Acidemia - other AEs
decreased respiratory muscle strength, hyperventilaion, dyspnea
Adverse consequences: alkalemia
cardiovascular, metabolic, CNS, others
Alkalemia - cardiovascular AEs
decreased coronary blood flow from arteriolar constriction
decreased anginal threshold; arrhythmias
Alkalemia - metabolic AEs
decrease in K+, Ca, and Mg (all important for electrical activity of the heart)
stimulation of anaerobic glycolysis
Alkalemia - CNS AEs
decrease cerebral blood flow
seizures
Alkalemia - other AEs
decrease respirations
Acid generation - diet
~1mEq/kg/day of acid consumed/day; from oxidation of proteins + fats
aerobic metabolism of glucose produces 15-20K mmol of CO2/day
nonvolatile acids also formed
Nonvolatile acids formed
anaerobic metabolism produces lactic acid and pyruvic acid
triglyceride oxidation produces acetoacetic acid and beta-hydroxybutyric acid
metabolism of sulfur-containing amino acids and phospholipids result in sulfuric and phosphoric acids
0.8 mEq H+ from nonvolatile acids/kg of body weight must be excreted daily
Acid regulation: 3 standard mechanisms
buffering, renal regulation, ventilatory regulation
Extracellular/intracellular buffering systems
first line defense
buffer: ability of a weak acid and its anion (base) to resist change in pH with addition of strong acid or base
buffers: bicarbonate/carbonic acid, phosphate, and protein
Extracellular/intracellular buffering systems -Bicarbonate principle buffer
rapid onset with intermediate capacity to control acid level
HCO3- buffer present in largest concentration extracellulary: supply of CO2 is unlimited, acidity can be controlled by HCO3- or the pCO2
ability of the kidneys + lungs to excrete and retain HCO3- and CO2 respectively
when acid is added, large quantities of CO2 can be exhaled very rapidly; body needs need HCO3- added to system in amount equivalent to H+ load ingested each day
Extracellular/intracellular buffering systems - phosphates
intermediate onset and capacity
extracellular inorganic phosphates limited activity
intracellular organic phosphates
calcium phosphates in bone relatively inaccessible
Extracellular/intracellular buffering systems - proteins
albumin/hemoglobin: rapid onset, limited capacity
more effective intracellular buffer vs extracellular buffer
Renal system regulation
kidney serves 2 main purposes: reabsorb filtered HCO3- and excrete H+ ions released from nonvolatile acids (help generate new HCO3-)