ACh Flashcards
What is the role of ACh as a CNS transmitter?
ACh is involved in various CNS functions, including attention, learning and memory, and arousal.
What are CNS nicotinic receptors?
CNS nicotinic receptors are a type of ionotropic receptor that responds to ACh and mediates fast synaptic transmission in the CNS.
What are CNS muscarinic receptors?
CNS muscarinic receptors are a type of metabotropic receptor that responds to ACh and mediates slower synaptic transmission in the CNS.
What are the functions of AChRs in the CNS?
AChRs in the CNS play a role in attention, learning and memory, arousal, and regulation of autonomic functions.
What are the different subtypes of CNS nicotinic receptors and how do they function?
There are several subtypes of CNS nicotinic receptors, including alpha4beta2 and alpha7 receptors. They function to mediate fast synaptic transmission and modulate neurotransmitter release.
What are the different subtypes of CNS nicotinic receptors and how do they function?
There are several subtypes of CNS nicotinic receptors, including alpha4beta2 and alpha7 receptors. They function to mediate fast synaptic transmission and modulate neurotransmitter release.
What are the different subtypes of CNS muscarinic receptors and how do they function?
There are several subtypes of CNS muscarinic receptors, including M1-M5 receptors. They function to modulate slow synaptic transmission and regulate various CNS functions.
What are some drugs that act on CNS ACh receptors and what are their actions?
Examples of drugs that act on CNS ACh receptors include cholinesterase inhibitors (which increase ACh levels) and anticholinergic drugs (which block ACh receptors). Their actions can have various effects on CNS functions, including cognitive enhancement or impairment.
What is ACh as a CNS transmitter?
ACh (acetylcholine) is a neurotransmitter that plays a crucial role in the central nervous system (CNS). It is synthesized in cholinergic neurons located in the brainstem, basal forebrain, and other regions of the CNS, and is involved in various CNS functions, including attention, learning and memory, arousal, and regulation of autonomic functions.
What receptors does ACh act on?
ACh acts on two main types of receptors in the CNS: nicotinic and muscarinic receptors. Nicotinic receptors are ionotropic receptors that mediate fast synaptic transmission, while muscarinic receptors are metabotropic receptors that mediate slower synaptic transmission.
What is the release of ACh regulated by?
The release of ACh in the CNS is regulated by cholinergic neurons, which send axons to innervate target neurons and release ACh into the synaptic cleft. ACh is then either degraded by the enzyme acetylcholinesterase or taken up by cholinergic neurons or glial cells, terminating its action.
