Acetylcholine And Cholinergic Receptors Flashcards
0
Q
What are nicotinic receptors?
A
-ligand-gated ion channel receptor
1
Q
What are the receptors responsive to acetylcholine?
A
Cholinergic receptors
- nicotinic
- muscarinic
2
Q
What are muscarinic receptors?
A
G-protein-coupled receptor
4
Q
Where are ligand-gates ions channel located?
A
-cholinergic neuromuscular junction of the somatic motor system and at the autonomic ganglia
5
Q
Where are G-protein-coupled receptors muscarinic receptor located?
A
-at the target organs of the parasympathetic nervous system
6
Q
Consequence of the neurotransmitter binding to G-coupled protein receptor
A
- stimulatory (Gq & Gs)
- inhibitory (Gi)
7
Q
Five subtypes of muscarinic receptor
A
M1 M2 M3 M4 M5
8
Q
M1 receptors
A
- associated with excitatory G-protein (Gq)
- generally found on neurons in the CNS but also in peripheral ganglia
- they control gastric secretion
9
Q
M2 receptors
A
- inhibitory (Gi)
- located in the heart
10
Q
M3 receptors
A
-linked to an excitatory G-protein (Gq)
- located predominantly at the autonomic target organs
- mainly secretory glands and sooth muscle
11
Q
M4 receptors
A
- inhibitory (Gi)
- more restricted to the CNS and are less well characterized.
- also located on salivary glands and the parasympathetic innervation of the eye.
12
Q
M5 receptors
A
- excitatory (Gq)
- more restricted to the CNS and are less well characterized.
- also located on salivary glands and the parasympathetic innervation of the eye.
