Acetaminophen Flashcards
1
Q
Acetaminophen effects (2) Mechanism:
A
Analgesic
Antipyretic (inhibits PGE2 production)
No anti-inflammatory, no anti-platelet
Mechanism: Inhibits a COX in the CNS
2
Q
Max dose of acetaminophen for adult?
A
4000 mg per day
3
Q
Contraindications:
A
Hepatic, renal diseases
Alcoholism
4
Q
Overdose leads to _______
Symptoms:
A
Hepatic necrosis
Symptoms: yellowing skin/eyes, sweating, stomach pain, tiredness
5
Q
Alcohol Toxicity/Overdose
Mechanism:
Antidote:
A
Acetaminophen metabolism produces toxic metabolite when in presence of alcohol.
Antidote is acetylcysteine, which converts the toxic to a nontoxic (mimics action of glutathione in body)
