ACE modules Flashcards
MAP or SBP is a product of?
SVR x CO
Cardiac output is a product of ?
CO = HR x SVR
Factors affecting SVR?
- Vascular tone
- Blood viscosity
Mechanisms of BP regulation?
- Fast neural response
- Slow humoral response
Sensory information about BP is detected by ?
- Stretch receptors - Baroreceptors
Location of baroreceptors?
- carotid sinus
- aortic arch
Pathways of baroreceptor sensing of BP information?
- Baroreceptors
- Afferent automonic fibres to medulla
The vasomotor center?
Area in the medulla involved in regulation of BP
Determinants of BP?
- Arteriolar diameter
Vasomotor centre mechanism?
- Activation of SNS
- Innervation of arterioles
- Smooth muscle contraction
- Vasoconstriction
Activators of vasomotor centre resulting in increased BP?
- Pain
- Emotion
Inhibitors of VMC resulting in lowering of BP?
- Increased firing of baroreceptors
Components of hormonal control of BP?
- Adrenaline / Noradrenaline (Adrenal medulla)
- Vasopressin (Hypothalamus)
- Angiotensin II (Renin-Angiotensin-Aldosterone system)
Actions of hormonal control of blood pressure? Compensatory mechanisms?
- Positive inotropy
- Vasoconstriction
- Fluid retention
Natural substances lowering BP? Potent arteriolar vasodilators?
- Histamine
- Nitric oxide
Sympathetic nerve endings ?
- Release Noradrenaline acting on alpha-1-receptors to cause vasoconstriction
Location of alpha-1-adrenoceptors?
- Skin
- Gut
- Kidney