Accessory Molecules of TCR Flashcards
part of lecture 8, slide 36
1
Q
CD3 function
A
signal transduction by TCR complex
2
Q
ζ function
A
signal transduction by TCR complex
3
Q
CD4 function
A
signal transduction
4
Q
CD8 function
A
signal transduction
5
Q
CD28 function
A
signal transduction (costimulation)
6
Q
CTLA-4 function
A
signal transduction (negative regulation)
7
Q
PD-1 function
A
signal transduction (negative regulation)
8
Q
LFA-1 function
A
adhesion
9
Q
What is the ligand for CD4?
A
class II MHC
10
Q
Where is class II MHC expressed?
A
antigen presenting cells
11
Q
What is the ligand for CD8?
A
class I MHC
12
Q
Where is class I MHC expressed?
A
all nucleated cells
13
Q
What is the ligand for CD28?
A
B7-1/B7-2
14
Q
Where is B7-1/B7-2 expressed?
A
antigen presenting cells
15
Q
What is the ligand for CTLA-4?
A
B7-1/B7-2
