Accessory Molecules of TCR

Question 1

CD3 function

Answer 1

signal transduction by TCR complex

Question 2

ζ function

Answer 2

signal transduction by TCR complex

Question 3

CD4 function

Answer 3

signal transduction

Question 4

CD8 function

Answer 4

signal transduction

Question 5

CD28 function

Answer 5

signal transduction (costimulation)

Question 6

CTLA-4 function

Answer 6

signal transduction (negative regulation)

Question 7

PD-1 function

Answer 7

signal transduction (negative regulation)

Question 8

LFA-1 function

Answer 8

adhesion

Question 9

What is the ligand for CD4?

Answer 9

class II MHC

Question 10

Where is class II MHC expressed?

Answer 10

antigen presenting cells

Question 11

What is the ligand for CD8?

Answer 11

class I MHC

Question 12

Where is class I MHC expressed?

Answer 12

all nucleated cells

Question 13

What is the ligand for CD28?

Answer 13

B7-1/B7-2

Question 14

Where is B7-1/B7-2 expressed?

Answer 14

antigen presenting cells

Question 15

What is the ligand for CTLA-4?

Answer 15

B7-1/B7-2

Question 16

What is the ligand for PD-1?

Answer 16

PD-L1/PD-L2

Question 17

Where is PD-L1/PD-L2 expressed?

Answer 17

antigen presenting cells, tissue cells, tumor cells

Question 18

What is the ligand of LFA-1?

Answer 18

ICAM-1

Question 19

where is ICAM-1 expressed?

Answer 19

antigen presenting cells, endothelium