Acantholytic Dyskeratosis

Question 1

Acantholytic dyskeratosis

DDX

Answer 1

Darier

Transient acantholytic dermatosis (Grovers)

Question 2

Darier’s disease

Clinical

Histology

Answer 2

Clinical: Autosomal dominant, greasy papules on head and neck

Histology:

1. Acanthosis
2. suprabasilar acantholytic dyskeratosis with corp ronds (dyskeratotic cells)
3. grains (parakeratotic cells)

Question 3

Transient acantholytic dermatosis (grovers)

Answer 3

Trunk of older males, itchy

3 patterns:

1. Spongiotic
2. PV-like suprabasilar acantholysis
3. Hailey-Hailey like full thickness acantholysis

DDX:

1. PV
2. HHD (need history)
3. Focal acantholytic dyskeratosis (incidental or associated with underlying lesion)