ABX: Use and Spectrum

Question 1

Covers MRSA

Answer 1

Ceftaroline
Vancomycin
Daptomycin
Gentamicin (+penicillin/cephalosporin)
Tigecycline
Macrolides
Clindamycin
Linezolid
Cotrimazole

Question 2

Covers MRSA + VRE

Answer 2

Daptomyxin
Gentamicin (+penicillin/cephalosporin)
Tigecycline (MRSA, VRE, VIR, Penicillin-resistant Streptococcus pneumonia)
Linezolid

Question 3

Covers gram - only

Answer 3

Monobactam (aztreonam)

Polymyxin B/ Polymyxin E (Colistin) (savage tx for MDR MO)

Question 4

Covers gram + only

Answer 4

Linezolid (MRSA, VRE) for tx of severe infection caused by gram + resistant to other ABX

Question 5

Broad spectrum

Fairly broad

Answer 5

Fosfomycin (uncomplicated UTI)
Cotrimoxazole (+,-, anaerobes)
Fluoroquinolones (+,-, anaerobes, atypical)

Penicillin, Cephalosporin

Question 6

Covers atypical

What are the atypical

Answer 6

Tetracycline (M C L R)
Macrolides (M C L R)
Fluoroquinolones (M C L)

Atypical: mycoplasma, rickettsia, chylamdia, legionella

Question 7

Mycoplasma Tx (ABX)

Answer 7

Fluoroquinolones (2nd line TB)

Ag (amikacin) (2nd line)

Question 8

(b-lactam, non b-lactam)

Covers gram +, - anaerobes

Answer 8

Penicillin V (No MSSA) G is IV/IM
Penicillinase-R Penicillin: Cloxacillin (first choice for MSSA)
Aminopenicillin
Ureidopenicillin (P)
Carboxypenicillin (P)

b-lactam/b-lactam (MSSA + bacteriodes)

Carbapenem (broadest -, against P and ESBL)

Question 9

Gram - coverage of the carbapenems

Answer 9

P E A
Imi Y R R
Dori, Mera Y M Y
Erta N N N

Pseudomonas, E. faecalis, Acinetobacter

Question 10

for immunocompromised against hiv

Answer 10

clindamycin and Cotrimoxazole: tx peumocytitis jiroveci in hiv pt

Question 11

Anti folate uses

Answer 11

sulphonamide: UTI
sulphadiazine/pyrimethamine: 1st line toxoplasmosis
2nd line malaria

trimethoprim: uti, ppl allergic to sulpha, better penetration than SMZ

CXS: uti, peumocytitis jiroveci, toxoplasmosis, nocardiosis

Question 12

bacteriodes

Answer 12

b-lactam/b-lactamase
clindamycin
moxifloxacin

Question 13

3Ps dont covered by tigecycline

Answer 13

pseudomonas, proteus, providencia

Question 14

Anaerobes

Answer 14

penicillin, carbapenem, vanco, teico, bacitracin, clindamycin, fluoroquinolones

Best for anaerobic infection: clindamycin
C.difficle: vanco, teico, bacitracin, metronidazole
Bacteriodes: b-lactam/b-lactamase, clindamycin, moxifloxacin

metronidazole: difficle and amoeba

Question 15

Bactericidal

Bacteriostatic

Answer 15

Cidal - BAMG
Beta lactam, AG, Metronidazole, Glycopeptides (vanco)

Static: Ms CLT
Macrolides, SXT, Clinda, Linezolid, tetracycline