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Clin Pharm > ABX Review > Flashcards

ABX Review Flashcards

1
Q

Pseudomonas Drugs

A

Pseudo Penis Forgets a Mother-pecking Condom(2)
Piptazo
FQ
Aminogycosides
Monobactam
Polymyxin
Cefepime, Carbapenem

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2
Q

Kill MRSA with

A

“Long Late Cram Sesh, Very Tired”
L-Lincosamide
L-Linezolid
C- Clindamycin
S-Sulfonamide
V-Vanco (IV)
T-TCN

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3
Q

What Drugs mentioned are very Nephrotoxic?

A

“A Very Angry “C”idney”
A-Amphotericin B
Vanco
Aminoglycosides- ATN
Carbapenems

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4
Q

What ABX (and antifungals) are Hepatotoxic?

A

All The DCRIMES
All-Azoles
The-Terbinafine
D- Doxycycline
C- Clindamycin
R- Rifampin
I- Isoniazid
M- Metronidazole
E- Erythro-like (not Azithro)
S- Sulfa

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5
Q

What Drugs inhibit CYP?

A

“Clarice is back at war, inhibit her”
Clarithromycin
Bactrim
Azoles
Wafarin -Check INR (may be high)
Inhibit CYP

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6
Q

What drugs induce CYP?

A

Ripe cervix= induce labor
Rifampin

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7
Q

What drugs cover Lyme Dz?

A

Lyme Dz “LATA”
Lyme
Augmented PCNS
TCN
Amoxicillin/Ampicillin

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8
Q

Anaerobe coverage above the diaphragm

A

“clear lungs”
Clindamycin-Lincosamide

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9
Q

Anaerobe coverage below the diaphragm

A

“My Tummy”
Metronidazole Tinidazole”

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10
Q

H.flu coverage

A

“BUM CAT”
B-Bactrim
U-Unasyn
M-Macrolides
C-Cefurixime
A-Augmentin
T-TCN

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11
Q

Bacteriostatic Drugs

A

“Static Like SMs Texts”
Like-Lincosamide
S-Sulfa
M-Macrolides
s
Texts- TCN

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12
Q

When would you use IV vs oral?

A

*Pt condition
*MRSA risk
*Don’t tolerate/absorb oral Rx
ie Crohns & gastric Bypass
*Outpt IV rx:
Dalbavancin & Aritavancin
both 1 IV infusion x2wks.
- These are NOT for IVDU

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13
Q

What abx inhibits 50s ribosome synthesis

A

Macrolides
Clindamycin

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14
Q

What abx inhibits 30S ribosome synthesis

A

Aminoglycosides
TCNs

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15
Q

What Abx inhibits 30S & 50S ribosome synthesis

A

Linezolid

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16
Q

What abx inhibits folic acid producion

A

Sulfonamides

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17
Q

What abx inhibit cell wall synthesis

A

PCN
Cephs
Vanco

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18
Q

What abx inhibits cell membrane synthesis

A

Polymyxin

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19
Q

What abx inhibits DNA gyrase

A

FQ

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20
Q

What abx inhibits RNA polymerase

A

Rifampin

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21
Q

DO PCNs cover MRSA?

A

no

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22
Q

Which 3 abx cause diarrhea?

A

Augmentin
Clindamycin
Erythromycin (pro motility agent)

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23
Q

What abx is given before surgery

A

Ancef (cefazolin)

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24
Q

what abx class for cellulitis,strep pharyngtits,syphillis?

A

Natural pcn

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25
Q

what are the aminopcns? can they cover lyme dz <8yo?

A

ampicillin/amoxicillin
yes

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26
Q

what abx are used for endocarditis prophylaxis?

A

ampicillin
amoxicillin

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27
Q

you are bit by a dog:
what is the bug?
What is the DOC?

A

Pasteurella
Augmentin (or unasyn)

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28
Q

you are bit by a dog:
Can the DOC cover dental infections? Why?

A

yes
covers anaerobes

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29
Q

you are bit by a dog:
Can the DOC also cover your AECB?
why?
what other drug class is an alternative?

A

yes
Hflu coverage

2nd gen ceph- Cefuroxime PO

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30
Q

you are bit by a dog:
Can the DOC cover lyme dz?
why?
What other abx cover this bug?

A

yes
covers borrelia burgdorfi
Amino-pcns (amoxicillin/ampicillin) & TCNs

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31
Q

you are bit by a dog:
also ate soft cheese. uh oh.
which bug?
is it covered by the abx for the dog bite?
What other drug covers this bug?

A

yes
Listeria

aminoPCN’s: Ampicillin/amoxicillin

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32
Q

Which PCN class covers staph and MSSA? Can they also cover Strep?

A

Anti-staph PCN
Nafcillin
Dicloxacillin

yes

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33
Q

Do the natural PCN cover staph?

A

nope

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34
Q

what ceph gen covers uncomplicated cystitis?

A

1st gen

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35
Q

you are dx w/Ghonorrhea, whoops. What is the bug morphology

A

gram - diplococci

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36
Q

you are dx w/Ghonorrhea,
What is DOC?

A

Ceftriaxone

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37
Q

you are dx w/Gonorrhea AND meningitis
what DOC? why?

A

Ceftriaxone, crosses BBB

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38
Q

what s/e do we worry about w/ceftriaxone

A

biliary sluge
pseudocholelithiasis

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39
Q

why do we not mix Tetracyclines with isotrentinoin (accutane)?

A

Pseudotumor cerebri (Idiopathic intracranial HTN)
TCNs are used as skin care abx-good to know

40
Q

You are hospitalized and have ESBL
what is DOC?

A

Carbapenems

41
Q

You are hospitalized and have ESBL
AND have Pseudomonas
DOC?
Can this class cover ventilator pna?

A

Carbapenems (not erta)
yes!

42
Q

2 bad s/e of carbapenems?

A

Seizures
Nephrotoxicity

43
Q

2 Drug classes that cover walking pna (mycoplasma)

A

TCNs
Macrolides

44
Q

2 drug classes that cover atypical pna (legionella)

A

TCN
Macrolides

45
Q

3 tic borne illnesses that TCN’s cover

A

Rickettsia, Ehrlichia, Borrelia

46
Q

Can you give TCN to kids <8 with tic illnesses

A

yes

47
Q

what 2 drug classes cause photosensitivity?

A

TCN
FQ

48
Q

what is the drug & dose for chlamydia?

A

Doxy 100mg BID x7d

49
Q

What 3 drugs/classes cause QT prolongation?

A

“FQt-AzAz”
Azithromycin
FQ’s
Azoles

50
Q

You hear a Whoop from your child
bug?
DOC?

A

Pertussis
Macolides

51
Q

Now you have the whoop cough
AND Chlamydia
DOC?
will this drug cover staph?

A

Macrolides
no

52
Q

You have urethritis and cervicitis
DOC?
Can you use this drug for CAP?

A

Macrolides
Yes- but as Azithro + Doxy

53
Q

You have an anerobic infect in lungs,
DOC?
Can this drug cover strep & Staph?

A

Clindamycin
yes

54
Q

What drug can you substitute for serious b lactam allergy in skin and soft tissue infections and strep pharyngitis
AND dental infect

A

Clindamycin

55
Q

What drug has high incidence of C-diff

A

Clindamycin

56
Q

What 2 drugs lose absorption when taken with Ca2+

A

TCN
FQ

57
Q

Name 8 ADRs of FQ’s

A

Arthropathy
Tendinopathy
CNS toxicity
QT prolongation
Photosensitivity
contraindicated in pregnancy/<18yo
Dysglycemia
Neuropathy

58
Q

What drug class causes dysglycemia

A

FQ

59
Q

What drug class is used for pyelonephritis?

A

FQ

60
Q

What drug class is used for prostatitis?

A

FQ

61
Q

What drug class is used for travelers diarrhea?

A

FQ

62
Q

What drug class is used for diverticulitis?

A

FQ + Metronidazole

63
Q

What drug class covers PCP tx & prevention

A

Sulfonamides

64
Q

What drug class covers Klebsiella & Proteus?

A

Sulfonamides

65
Q

What drug class causes retentio of potassium?

A

BK-Big (Bactrim) K+
Sulfonamides

66
Q

What drug class needs renal dosing

A

Sulfonamides

67
Q

What drug class causes Type 1 & 4 Hypsersensitivity rxns? Name them

A

Sulfonamides
Type 1- sulfa rash
Type 4- SJS & TEN

68
Q

What drug class causes myelosuppression?

A

Sulfonamides

69
Q

What 2 drug classes cause Hemolytic anemia in G6PD?

A

Sulfonamides (Bactrim)
Nitrofuratonin (Macrobid)

70
Q

What 4 drug classes can cover Uncomplicated cystitis (not pyelo)?
What 3 classes cover Complicated UTI (pyelo)?

A

1st gen cephalosporins (Cefazolin, Cefalexin)
Sulfonamides
Nitrofuratonin (Macrobid)
Fosfomycin

3rd gen cephs (Ceftriaxone)
Carbapenems
FQ

71
Q

What drugs can cover:
Fungal UTI?
ESBL?

A

Fluconazole

Carbapenems
Nitrofuratonin (Macrobid)
Fosfomycin (Monurol)

72
Q

you are dx with protozoas: giardia & trich (oh dear)
DOC? esp w/what other drug?

A

Metronidazole
w/FQ

73
Q

You are dx with BV (yikes)
DOC?

A

Nitroimidazoles (Metronidazole & tinidazole)

74
Q

What drug causes a disulfram rx w/ETOH?
what is a disulfram rxn?

A

Metronidazole & Tinidazole
facial flushing, tachy, N/V/D

75
Q

What drug class causes fetotoxicity in 1st trimester

A

Metronidazole & tinidazole

76
Q

What drug class do you need to measure peaks & troughs (narrow therapeutic window)?
What other class same same but not for oral

A

Aminoglycosides

Glycopeptides (Vanco IV)

77
Q

What drug clas can cause ATN?

A

Aminoglycosides

78
Q

What 2 abx classes (&1 spec abx) are linked to ototoxicity?

A

Aminoglycosides: Gentamycin
Vancomycin

79
Q

Ototoxicity & nephrotoxicity
Which can be reversible? how?

A

Nephrotoxicity- stop the drug

80
Q

What is Red Man syndrme?

A

A histamine response to fast push IV Vanco

81
Q

Do nitrofuratonin and monurol (fosfomycin) have systemic absorption?

A

no
only works in the bladder

82
Q

Which TB drugs ↑ liver enzymes (esp w/etoh)

A

Rifampin & Isoniazid

83
Q

What can you take with isoniazid to decrease the periph neuropathy?

A

B6- Pyridoxime

84
Q

Which cephalosporin gen has BROAD COVERAGE and MRSA?

A

Next gen (5th) Ceftaroline (Teflaro)

85
Q

Which drug class covers Mycoplasma (atypical pna), H.pylori, Chlamydia, and Pertussis

A

Macrolides

86
Q

What drugs cause metallic taste?

A

Clarithroycin
Nitroimidazole (Metronidazole & Tinidazole)

87
Q

What is red lobster syndrome?

A

A general redness caused by riampin (with orange urine)

88
Q

What drug causes color blindness?

A

Ethambutol

89
Q

What drug causes polyarthralgia?
What can you do to treat it?

A

Pyrazidimine
NSAIDS

90
Q

Cat C Drugs

A

“F**k Bad Children”
FQ
Bactrim
Clarithromycin

91
Q

Cat D Drugs

A

“CATs are Destructive”
C- Cat D
Aminoglycosides
TCNs

92
Q

FAST AbX

A

FQ- Arthtropathy
Aminoglycosides- Ototoxicity
S-Sulfonamides- infantile kernicterus
T-TCN- Bone & teeth probs

93
Q

Type 1 Rxn & 2 examples

A

IgE
anaphylaxi, urticaria

94
Q

Type II & 2 examples

A

“B and the number 2 are complements”
IgG and complement
Bone marrow suppression & blood transfusion rxn

95
Q

Type III rxn & 4 examples

A

Ab-Ag complexes
PSGN
Serum Sickness
SLE nephritis
RA

96
Q

Type IV rxn & 4 examples

A

T-cell (delayed)
SJS
TEN
Organ txfr
Poison ivy (contact dermatitis)

97
Q

Are we gonna crush this test?

A

HELL YEAH

Clin Pharm (6 decks)

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