Abx - diseases

Question 1

Strep pharyngitis: organisms and drugs

Answer 1

Organisms: Group A Strep, Strep pyogenes

Drugs: Penicillin V (PO) or G, Amoxicillin (PO)

Question 2

Rhinosinusitis: organisms and drugs

Answer 2

Organisms: S. pneumoniae, H. influenza, M. catarrhalis, S. aureus

Drugs: Augmentin, doxy, clinda + 3rd gen cephalosporin, resp FQ

Question 3

Otitis media: organisms and drugs

Answer 3

Organisms: S. pneumoniae, M. catarrhalis, H. influenza, Respiratory viruses

Drugs: Amoxicillin or amoxicillin clavulanate, azithromycin, 3rd gen ceph

Question 4

Community acquired pneumonia: organisms and drugs

Answer 4

Organisms: Strep pneumoniae (resp G+), H. influenza (resp G-),
atypicals: M. pneumoniae, C. pneumonia, legionella, P. aeruginosa, CA-MRSA

Drugs:

• Outpatient, no comorbidities: Macrolide (Azithromycin), Doxycycline
• Outpatient, comorbidities: FQ, Beta lactam plus macrolide
• Inpatients/ non-ICU: Resp FQ (1st line), Beta lactam plus macrolide, or any other combo of cell wall synthesis inhibitor plus protein synthesis inhibitor
• -if p. aeruginosa: antipseud. B-lactam (piperacillin/tazobactam, ceftazidime, cefepime, impenem) + resp FQ
• -if CA-MRSA: add vanco or linezolid

Question 5

urinary tract infection: organisms and drugs

Answer 5

Organisms: E. coli, proteius, k. pneumoniae, s. saprophyticus

Drugs:

• uncomplicated: nitrofuantoin, fosfomycin, TMP-SMX
• complicated: levoflox, ciproflox, cephalosporin, augmentin

Question 6

Gonococcal infeciton: organisms and drugs

Answer 6

Organisms: N. Gonorrhoae

Drugs: Ceftriaxone (IM) or Cefixime (PO) PLUS Azithromycin (PO)

Question 7

Syphilis: organisms and drugs

Answer 7

Organisms: Tremponema pallidum

Drugs:

• Primary or latent: DOC = PCN G or benz PCN G (IM), doxy, cephtriaxone
• Tertiary or neurosyphilis: PCN G (IV) or doxy (PO), or tetracycline

Question 8

SSTI (cellulitis): organisms and drugs

Answer 8

Organisms: Group A strep, S. aureus

Drugs: Mupirocin (topical)

• If not responding to topical ABX:
  a. Lenezolid (PO, IV)
  b. TMP-SMX (PO, IV)
  c. Doxy (PO)
  d. Vanco (IV): DOC for MRSA, DOC if PCN allergy
  e. Minocylcine (PO, IV)
  f. Daptomycin (IV)
  g. Dicloxacillin (PO)
  h. Cephalexin (PO)
  i. Clindamycin (PO, IV): DOC if PCN allergy
  j. Nafcillin (IV): Parenteral DOC for MSSA
  k. Cefazolin (IV)
  l. Ceftaroline (IV)