Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

ECC-soph > ABX-Buckley > Flashcards

ABX-Buckley Flashcards

1
Q

Penicillins

A

Ampicillin

Amoxicillin

Pen G

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Penicillins MOA, classification

A
  • MOA: bind to penicillin binding proteins to disrupt cell wall synthesis
  • bactericidal, time dependent
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Penicillins spectrum

A
  • mainly gram positive, some activity against gram negatives but not reliable
  • active against most anaerobes except bacteroides
  • little activity against pseudomonas
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Cephalosporins

A

1st gen: cefazolin, cephalexin

2nd gen: cefoxitin, cefuroxamine

3rd gen: cefotaxime, ceftiofur, ceftriaxone, cefpodoxime, ceftazidime

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Cephalosporins MOA, classification

A
  • MOA:inhibit cell wall synthesis
  • bactericidal, time dependent
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Cephalosporins spectrum

A

As you go from 1st to 3rd generation, the spectrum changes from gram positive (g1) to mainly gram negative (g3)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Lincosamides

A

clindamycin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Lincosamides MOA, classification

A
  • MOA: prevent protein synthesis by binding to 50S ribosome
  • bacteriostatic, time dependent
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Lincosamide spectrum

A
  • clindamycin (only lincosamide taught in this course) has good activity against gram positive aerobes including MRSA and against anaerobes
  • resistance is about 50% in Bacteroides spp.
  • they have little efficacy against gram negative organisms.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Potentiated Penicillins

A

ampicillin-sulbactam (unasyn), amoxicillin-clavulanate (clavamox)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Potentiated Penicillins MOA, classification

A
  • MOA: inhibit cell wall synthesis
  • bactericidal, time dependent
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Potentiated Penicillins spectrum

A
  • good activity against gram positive organism, improved activity against gram negative bacteria as compared to regular penicillins
  • improved activity against Bacteroides spp. (90% effective)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Fluoroquinolones

A

enrofloxacin (baytril), marbofloxacin, ciprofloxacin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Fluoroquinolones MOA, classification

A
  • MOA: bind to DNA gyrase and topisomerase IV to prevent gene transcription
  • bactericidal, concentration dependent
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Fluoroquinolones spectrum

A
  • good activity against gram negative organisms, poor activity against gram positives or anaerobes
  • high doses can be used for Pseudomonus spp.
  • toxic to cats at high doses (>5mg/kg = retinal degeneration)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

new fluoroquinolone

A

pradofloxacin

  • not reported as being toxic in cats
  • broader spectrum of action, gram positive and some anaerobes
  • not labeled for use in dogs
17
Q

Aminoglycosides

A

amikacin, gentamycin

18
Q

Aminoglycosides MOA, classification

A
  • MOA: bind to 30S ribosome and prevent protein synthesis
  • bactericidal, concentration dependent
19
Q

Aminoglycosides spectrum

A
  • excellent activity against gram negative organisms including resistant E. coli
  • can be synergistic with penicillins in the treatment of some gram positive infections such as enterococcus, MRSA
  • nephrotoxic!!
20
Q

Tetracyclines

A

Doxycycline, minocycline, tetracycline, oxytetracycline

21
Q

Tetracyclines MOA, classification

A
  • MOA: bind to 30S ribosome to inhibit protein synthesis
  • bactericidal
22
Q

Tetracyclines spectrum

A
  • excellent penetration to lung
  • good spectrum against gram positive bacteria, tick borne pathogens, Leptospira and Mycoplasma spp.
23
Q

Carbapenems

A

Imipenem, meropenem

24
Q

Carbapenems MOA, classification

A
  • MOA: inhibit cell wall synthesis
  • bactericidal, time dependent
25
Q

Carbapenems spectrum

A
  • excellent broad spectrum activity (gram positive, gram negative, and anaerobes
  • no activity against MRSA, limited against MDR enterococcus
  • expensive, injectable only
  • last resort drug
26
Q

Metronidazole MOA, classification

A
  • MOA: causes DNA strand breaks
  • time dependent
27
Q

Metronidazole spectrum

A
  • excellent activity against anaerobes and protozoa
  • at high doses it is associated with development of vestibular signs (d/c drug, CS disappear in a few days)
28
Q

Chloramphenicol MOA, classification

A
  • MOA: binds to 50S ribosome
  • bacteriostatic
29
Q

Chloramphenicol spectrum

A
  • gram positive and gram negative
  • good for MDR Enterococcus spp. and E. coli
  • risk of irreversible bone marrow suppression in humans
  • take care

ECC-soph (1 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions